ossification of the posterior longitudinal ligament of the spine

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ossification of the posterior longitudinal ligament of the spine

A common (up to 4% in Asians) autosomal recessive myelopathy (OMIM:602475), which can cause spinal-cord compression leading to tetraparesis.
 
Imaging
Dagger sign is typically seen in T4-T7.

Molecular pathology
OPLL is cause by:
(1) A defect of COL6A1, which encodes collagen VI, a cell binding collagen; and
(2) Loss of function mutations in ENPP1, which encodes a transmembrane glycoprotein that regulates soft tissue calcium and bone and joint cartilage mineralisation by generating pyrophosphate (PPi), a physiological inhibitor of hydroxyapatite crystal formation and a suppressor of chondrogenesis.
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References in periodicals archive ?
In our study, we found two (4.7%) cases of isolated OPLL, both in male patients with a mean age of 58 years.
Distribution of Diagnosis by MRI Diagnosis Frequency Percent AAD 1 2.3% ADEM 1 2.3% AVM 1 2.3% CSM 25 58.1% HRM 3 7.0% MS 2 4.7% NMO 1 2.3% OPLL 2 4.7% RAM 1 2.3% RDM 1 2.3% SYNX 3 7.0% TBM 2 4.7% Total 43 100.0%
MAGNETIC RESONANCE IMAGING IN EVALUATION OF NON-TRAUMATIC AND NON-NEOPLASTIC CASES OF CERVICAL MYELOPATHY--A STUDY
OPLL frequently coexists with OALL, possibly causing spinal cord compression and symptomatic myelopathy.
Pyogenic Spondylitis Caused by Methicillin-Resistant Staphylococcus aureus Associated with Tracheostomy followed by Resection of Ossification of the Anterior Longitudinal Ligament
A previous study found that OPLL is the most significant risk factor for CSFL.[sup][16] This conclusion, combined with the finding of gender disparity in the prevalence of OPLL,[sup][30],[31],[32] may explain the link between being female and CSFL.
Patients with ossified ligaments, including OPLL and OLF, have a higher likelihood of DT and CSFL.[sup][7],[15],[16],[18],[23] The underlying issue is the frequent appearance of strong adhesions or even ossified dura in these patients.[sup][7],[8],[21],[23],[27] OPLL has been reported as the most significant risk factor for CSFL.[sup][16] Therefore, surgical procedures involving the extirpation of OPLL should be performed with profound caution.
Cerebrospinal Fluid Leakage after Thoracic Decompression
(19) It was the first genetic study of OPLL and one of the first successful studies in all the linkage studies of common diseases.
Genomic study of ossification of the posterior longitudinal ligament of the spine
We performed a 2-stage surgery with LLIF and posterior decompression and fusion because of concomitant OYL at L3/4, OPLL at L4/5, anterior spondylolisthesis of L4 vertebra, and anticipated adhesions between the thecal sac and the ossified lesion.
Lateral Lumbar Interbody Fusion for Ossification of the Yellow Ligament in the Lumbar Spine: First Reported Case
Our results suggest that laminoplasty may be a better choice for patients with a severely stenotic spinal canal, especially in cases where the spinal canal area is less than half that of the bony spinal canal or in cases of OPLL, because of its ability to achieve a greater degree of enlargement.
Comparison of Functional and Radiological Outcomes Between Two Posterior Approaches in the Treatment of Multilevel Cervical Spondylotic Myelopathy
The fact that the spinal cord lesion caused only the selective unilateral C5 palsy was unclear; the longitudinal spinal cord lesion including the C5 motor segment after the first surgery and the left-oriented OPLL could partly explain that due to the ischemia-reperfusion injury [7].
A Delayed Postoperative C5 Palsy due to Spinal Cord Lesion: A Typical Clinical Presentation but Unusual Imaging Findings
This paper presents the results on a monolithic microwave integration of the optoelectronic (O/E) phase detector, which is one of the essential parts of optical phase-locked loops (OPLL).
A 2 to 10 GHz GaAs MMIC optoelectronic phase detector for optical microwave signal generators
We encountered a patient with progressing bilateral severe C5 palsy following posterior decompression and fusion for cervical ossification of posterior longitudinal ligament (OPLL).
A Case of Successful Foraminotomy for Severe Bilateral C5 Palsy following Posterior Decompression and Fusion Surgery for Cervical Ossification of Posterior Longitudinal Ligament
Existing systems use an optical phase-locked loop (OPLL) with laser diode pumped YAG sources.[9] While such lasers have high spectral purity and are relatively easy to phase lock, their complexity, high cost and mechanical fragility may limit their application.
Optical beamforming techniques for phased-array antennas

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