ossification of the posterior longitudinal ligament of the spine

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ossification of the posterior longitudinal ligament of the spine

A common (up to 4% in Asians) autosomal recessive myelopathy (OMIM:602475), which can cause spinal-cord compression leading to tetraparesis.
 
Imaging
Dagger sign is typically seen in T4-T7.

Molecular pathology
OPLL is cause by:
(1) A defect of COL6A1, which encodes collagen VI, a cell binding collagen; and
(2) Loss of function mutations in ENPP1, which encodes a transmembrane glycoprotein that regulates soft tissue calcium and bone and joint cartilage mineralisation by generating pyrophosphate (PPi), a physiological inhibitor of hydroxyapatite crystal formation and a suppressor of chondrogenesis.
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References in periodicals archive ?
In our study, we found two (4.7%) cases of isolated OPLL, both in male patients with a mean age of 58 years.
Distribution of Diagnosis by MRI Diagnosis Frequency Percent AAD 1 2.3% ADEM 1 2.3% AVM 1 2.3% CSM 25 58.1% HRM 3 7.0% MS 2 4.7% NMO 1 2.3% OPLL 2 4.7% RAM 1 2.3% RDM 1 2.3% SYNX 3 7.0% TBM 2 4.7% Total 43 100.0%
A previous study found that OPLL is the most significant risk factor for CSFL.[sup][16] This conclusion, combined with the finding of gender disparity in the prevalence of OPLL,[sup][30],[31],[32] may explain the link between being female and CSFL.
Patients with ossified ligaments, including OPLL and OLF, have a higher likelihood of DT and CSFL.[sup][7],[15],[16],[18],[23] The underlying issue is the frequent appearance of strong adhesions or even ossified dura in these patients.[sup][7],[8],[21],[23],[27] OPLL has been reported as the most significant risk factor for CSFL.[sup][16] Therefore, surgical procedures involving the extirpation of OPLL should be performed with profound caution.
(19) It was the first genetic study of OPLL and one of the first successful studies in all the linkage studies of common diseases.
We performed a 2-stage surgery with LLIF and posterior decompression and fusion because of concomitant OYL at L3/4, OPLL at L4/5, anterior spondylolisthesis of L4 vertebra, and anticipated adhesions between the thecal sac and the ossified lesion.
Our results suggest that laminoplasty may be a better choice for patients with a severely stenotic spinal canal, especially in cases where the spinal canal area is less than half that of the bony spinal canal or in cases of OPLL, because of its ability to achieve a greater degree of enlargement.
The fact that the spinal cord lesion caused only the selective unilateral C5 palsy was unclear; the longitudinal spinal cord lesion including the C5 motor segment after the first surgery and the left-oriented OPLL could partly explain that due to the ischemia-reperfusion injury [7].
This paper presents the results on a monolithic microwave integration of the optoelectronic (O/E) phase detector, which is one of the essential parts of optical phase-locked loops (OPLL).
We encountered a patient with progressing bilateral severe C5 palsy following posterior decompression and fusion for cervical ossification of posterior longitudinal ligament (OPLL).
Existing systems use an optical phase-locked loop (OPLL) with laser diode pumped YAG sources.[9] While such lasers have high spectral purity and are relatively easy to phase lock, their complexity, high cost and mechanical fragility may limit their application.