olivopontocerebellar atrophy

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atrophy

 [at´ro-fe]
1. decrease in size of a normally developed organ or tissue; see also wasting.
2. to undergo or cause such a decrease. adj., adj atroph´ic.
acute yellow atrophy massive hepatic necrosis.
circumscribed cerebral atrophy pick's disease.
disuse atrophy atrophy of a tissue or organ as a result of inactivity or diminished function.
gyrate atrophy of choroid and retina a rare hereditary, slowly progressive atrophy of the choroid and pigment epithelium of the retina; inherited as an autosomal recessive trait.
juvenile spinal muscular atrophy Kugelberg-Welander syndrome.
Leber's optic atrophy Leber's optic neuropathy.
lobar atrophy pick's disease.
myelopathic muscular atrophy muscular atrophy due to lesion of the spinal cord, as in spinal muscular atrophy.
olivopontocerebellar atrophy any of a group of progressive hereditary disorders involving degeneration of the cerebellar cortex, middle peduncles, ventral pontine surface, and olivary nuclei. They occur in the young to middle-aged and are characterized by ataxia, dysarthria, and tremors similar to those of parkinsonism.
peroneal atrophy (peroneal muscular atrophy) progressive neuromuscular atrophy.
progressive neuromuscular atrophy hereditary muscular atrophy beginning in the muscles supplied by the fibular (peroneal) nerves, progressing slowly to involve the muscles of the hands and arms. Called also peroneal or peroneal muscular atrophy and Charcot-Marie-Tooth disease.
senile atrophy the natural atrophy of tissues and organs occurring with advancing age.
spinal muscular atrophy progressive degeneration of the motor cells of the spinal cord, beginning usually in the small muscles of the hands, but in some cases (scapulohumeral type) in the upper arm and shoulder muscles, and progressing slowly to the leg muscles. Called also Aran-Duchenne disease, Cruveilhier's disease, and Duchenne's disease.
subacute yellow atrophy submassive necrosis of the liver associated with broad zones of necrosis, due to viral, toxic, or drug-induced hepatitis; it may have an acute course with death from liver failure occurring after several weeks, or clinical recovery may be associated with regeneration of the parenchymal cells.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ol·i·vo·pon·to·cer·e·bel·lar at·ro·phy

a group of genetically distinct, mostly autosomal dominant progressive neurologic diseases characterized by loss of neurons in the cerebellar cortex, basis pontis, and inferior olivary nuclei; results in ataxia, tremor, involuntary movement, and dysarthria; five clinical types (four with dominant in heritance, one with recessive) have been described, each characterized by additional findings, such as sensory loss, retinal degeneration, ophthalmoplegia, and extrapyramidal signs. Several loci are involved, autosomal dominant [MIM*164400-*164600] and recessive [MIM*258300].
See also: spinocerebellar ataxia.
Farlex Partner Medical Dictionary © Farlex 2012

olivopontocerebellar atrophy

A disease characterized by degeneration of neurons in the cerebellum, pons, and inferior olives of the brain, typically resulting in ataxia.
See also: atrophy
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
This data strongly suggests very few Canadian lawyers work repeatedly with OPCA clients.
The 29 non-relative layperson representatives identified in 74 decisions were cross-checked with known OPCA gurus, which showed a high correspondence (20 of 29: 69% of the total).
The preceding data has restricted value to establish quantitatively what kinds of OPCA activities and lawyer representation have actually occurred in Canadian courtrooms.
First, the process to accumulate the Dataset all but guarantees the Dataset is incomplete and that there remain many additional reported, but as of yet unidentified, Canadian OPCA decisions.
Second, reported decisions are unlikely to be a representative and random sample of actual OPCA activities in Canadian courts and how lawyers are involved in OPCA litigation.
Hypothetically this, may then lead to an overrepresentation of written OPCA decisions where a lawyer was involved.
That creates some confidence that year-to-year variations may reflect actual changes in OPCA litigation patterns.
However, with some OPCA litigants, ideology and philosophy, conspiratorial belief, and a lack of realism makes lawyer representation all but impossible.
A person adopted and advanced OPCA strategies which has negative legal consequences.
The OPCA litigant population can be divided by their motivation and behavior into several functional subclasses.
First, "Fighters and Believers" use OPCA strategies for personal advantage, but are also immersed in a conspiratorial and paranoid social space, the OPCAsphere.
A second and probably largely hypothetical subtype are "Accidental" OPCA SRLs, who happen on OPCA schemes, perhaps through Internet searches for legal resources, and are unaware this information is legally incorrect.