BMP7

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BMP7

A gene on chromosome 20q13 that encodes bone morphogenetic protein-7, which plays a key role in cartilage formation, osteoblast differentiation, renal development and repair, and induces the production of SMAD1.
References in periodicals archive ?
OP-1 demonstrates that the first wave of these next generation therapies are already being used by physicians treating patients.
The third major market approval for OP-1 confirms our confidence in the role of regenerative therapeutics in the future of medicine," stated Doros Platika, MD, Chairman of Curis.
Stryker stated in its press release that it anticipates commercial launch of OP-1 in the European Union to begin in the third quarter of 2001.
The statements in this news release that are not historical facts are forward-looking statements that involve risks and uncertainties including, without limitation, risks associated with the inherent uncertainty of pharmaceutical research, product development, regulatory approval and commercialization, the regulatory status of OP-1, status of human clinical trials, the impact of competitive products, patents, patent litigation, product liability, third party reimbursement, and other risks and uncertainties associated with the biotechnology industry.
As one of the first regenerative medicine products recommended for approval in the world, OP-1 validates the rich product pipeline under development at Curis," said Dr.
The product recommended for marketing authorization is a combination of the OP-1 protein and a collagen carrier in a wetted paste, which is surgically implanted into the bone defect.
This study confirms the effect of OP-1 in an important model of chronic renal failure.
The study showed that animals treated with OP-1 experienced reduced fibrosis and had less damage to renal tubules where key absorptive events occur, than animals in the ACE inhibitor and control groups.
This preclinical study indicates that OP-1 can restore dopamine levels in an animal model of the disease," commented Paula C.