orotidylic acid decarboxylase

(redirected from OMP decarboxylase)

o·rot·i·dyl·ic ac·id de·car·box·yl·ase

an enzyme that catalyzes the conversion of OMP to UMP and CO2; a defect or inhibition of this enzyme results in orotic aciduria and orotidinuria; this enzyme is a part of pyrimidine biosynthesis. Compare: uridylic acid synthase.
Synonym(s): OMP decarboxylase
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In filamentous fungi, pyrimidine auxotrophs obtained through inactivation of the OMP decarboxylase gene (usually designated pyrG) are auxotrophic for uridine and/or uracil and are resistant to 5-FOA [5, 6].