OLR1


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OLR1

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain receptor which mediates the recognition, internalisation and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. It is also a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria, as well as for HSP70 protein, which is involved in antigen cross-presentation to naïve T-cells. OLR1 is also involved in inflammation, acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
References in periodicals archive ?
Effects of different genotypes of OLR1 gene SNP loci on carcass quality traits
The OLR1 gene was reported to possess complex biological functions [14], especially regarding degradation of low-density lipoprotein and glucose metabolism in liver.
The bovine OLR1 gene localizes on chromosome 18, has 6 exons [11], and is highly expressed in lung, liver and adipose tissue [9].
Another study was carried out to reveal haplotype and phylogenetic analysis of OLR1 gene in Jaffarabadi and Surti by Shabir et al.
Borgiani et al., "Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction," Journal of Medical Genetics, vol.
Vecchione et al., "Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population," PLoS One, vol.
Beecham et al., "A candidate gene study revealed sex-specific association between the OLR1 gene and carotid plaque," Stroke, vol.
OLR1 gene has been reported to affect long chain fatty acid composition of milk.
For the purpose of analysis of OLR1 protein in river buffaloes, standard three-dimensional protein model of OLR1 was retrieved from RCSB-PDB No-1YXJ (www.rcsb.org/pdb/explore.do?structureId).
Residues A68G and K89E were not found in some functionally significant region but R181T was found as part of Domain-3 of the OLR1 protein (Fig-3) which was strongly associated with fat synthesis.
According to the instructions from the normal agarose gel DNA recovery kit, the specific band of GB pig OLR1 gene was recovered from 1.5% normal agarose gel, the recovery product was then connected to pMD-19T vector, and transformed to competent cells for sequencing.
Homology alignment and protein structure analysis for OLR1 in pig adipose tissue