OLR1


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OLR1

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain receptor which mediates the recognition, internalisation and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. It is also a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria, as well as for HSP70 protein, which is involved in antigen cross-presentation to naïve T-cells. OLR1 is also involved in inflammation, acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
References in periodicals archive ?
The expression characteristic of OLR1 in adipose tissue at different MA and in different economic types of pigs
Real time fluorescence quantitative PCR was employed to detect the expression abundance of OLR1 and inner-reference [beta]-actin in adipose tissues of 2, 5 and 10 MA LW and 5 MA GB pigs.
Analysis for expression correlation between OLR1 and lipid metabolism related genes in pig adipose tissue
In order to further explore the role of OLR1 in lipid deposition, we investigated the correlation between the relative expression of OLR1 mRNA and the mRNAs of five lipid metabolism and adipogenesis related genes, PPAR[gamma]2, FAS, SREBP-1c, C/EBP[alpha] and TGH.
Since then, OLR1 has been of interest because a close relationship between OLR1 and atherosclerosis has been acknowledged (Chen and Du, 2007).
We aligned the OLR1 CDS of pig adipose tissue with those of related species and found that OLR1 of pig adipose tissue has the highest homology with the cattle (84%), and the second highest is with human (79%).
As no research on the expression characteristics of OLR1 in pig tissues has been reported, we studied the expression abundance changes of OLR1 in various pig tissues.
In order to verify the association of the expression of OLR1 with lipid accumulation, we studied the expression of OLR1 in subcutaneous adipose tissue from pigs at different months of age and of different economic types.
The OLR1 has affinity for multiple ligands and exhibits complex biological functions.
In our experiment we did not observe a correlation between the expression of OLR1 and that of C/EBPa in adipose tissue.
In summary, OLR1 was increased with age and fat accumulation in porcine adipose tissue.