Other risk factors that have been associated with the development of this disease are the use of inducing drugs such as OKT3
(muronamab) and thymoglobulin, anticalcineurinic agents (cyclosporinee, tacrolimus), other viral infections (cytomegalovirus and hepatitis C), among others (3,5).
Existe una relacion sinergica importante entre los siguientes factores de riesgo: seronegatividad pretrasplante para EBV discordancia para CMV y tratamiento con OKT3
The cell product in the flask precoated with RetroNectin and OKT3
was named R-CIK cells, while the cell product in the flask precoated with OKT3
only was named OKT-CIK cells.
Standard transplant physician orders were typed up and copied to put in patients' charts, and protocols for dangerous medications, such as anti-lymphocyte globulin and OKT3
, were standardized and written, and the staff were educated.
Categories of drugs that have been most frequently associated with D- HUS include anti-cancer molecules (mitomycin, cisplatin, bleomycin, and gemcitabine), immunotherapeutics (cyclosporine, tacrolimus, OKT3
, IFN and quinidine) and antiplatelet agents (ticlopidine and clopidogrel).
CMV enfeksiyonu riski ayrica akut rejeksiyon tedavisi sirasinda kullanilan bolus steroid, anti-lenfosit globulin ve OKT3
tedavisi sirasinda da artar.
In vivo generation of C4d, Bb, iC3b, and SC5b-9 after OKT3
administration in kidney and lung transplant recipients.
Rejection episodes were treated with 1 gm methylprednisolone and a five-day taper; and, in refractory, cases with Muromonab OKT3
(Ortho Biotech, Bridgewater, NJ) until 2000 and rabbit anti-thymocyte globulin (Genzyme Corp, Cambridge, MA) from 2000 to present.
Consequently, monitoring the PCT concentration to demonstrate the presence of a bacterial infection or an AR would not be useful during the first days after the introduction of treatment with OKT3
or antithymocyte globulin.
106) But that combo proved too toxic, and it promptly spawned antibodies against OKT3
In the case of biopharmaceuticals, recombinant human insulin was the first product to be approved by the USFDA in the year 1982, to be followed by the recombinant hepatitis B vaccine and the first monoclonal antibody (Orthoclone OKT3
used to prevent rejection during kidney transplants) in the year 1986.
Peripheral blood lymphocyte subsets were determined by using a flow cytometer (Cytoron Absolute, Ortho, Raritan, N J, USA) after incubation with monoclonal antibodies OKT3
, OKT4, and OKT8 (Ortho).