ovarian hyperstimulation syndrome

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ovarian hyperstimulation syndrome

iatrogenic development of ovarian hyperstimulation that occurs when the luteotropic effects of human chorionic gonadotropin are exaggerated in a cycle in which ovarian stimulation has been done as a component of infertility treatment. The human chorionic gonadotropin is administered exogeneously to trigger ovulation after gonadotropin stimulation. It is present endogenously after implantation. Syndrome includes, to varying degrees, abdominal distention, potentially massive ovarian enlargement, and third spacing of vascular volume. It can range from moderate discomfort to life-threatening ovarian enlargement and fluid shifts.

Farlex Partner Medical Dictionary © Farlex 2012

ovarian hyperstimulation syndrome

OHSS

A potentially life-threatening complication that may occur in women receiving drugs to stimulate ovulation. The acute onset occurs within the first week ovulation is induced and is characterized by marked cystic ovarian enlargement, ascites, hydrothorax, arterial hypotension, tachycardia, hemoconcentration, oliguria, sodium retention, hypernatremia, and in severe cases renal failure. The condition is usually mild if the diameter of the ovary is less than 8 cm; moderate if 8 to 12 cm; and severe if greater than 12 cm.

Treatment includes symptomatic therapy to maintain circulatory function, bedrest, a low-sodium diet, and diuretic therapy. The life-threatening possibility can be avoided with close monitoring and withholding of drugs if ovarian response becomes excessive.

ovarian hyperstimulation syndrome

Ovarian enlargement, the production of multiple ovarian cysts, increased capillary permeability with generalized oedema and intravascular fluid depletion, SHOCK, and sometimes even death. The syndrome, which is uncommon, is caused by gonadotropin medical treatment to stimulate ovulation. Rarely, it may occur spontaneously during pregnancy as a result of a mutation in the gene for the follicle-stimulating hormone receptor.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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In the Gynecology and Obstetrics Clinic "Narodni Front" a case control study was conducted on 50 female patients with severe forms of OHSS in the period from January 2008 to March 2015.

Risk of spontaneous preterm labor in pregnancies achieved by in vitro fertilization and complicated with severe form of ovarian hyperstimulation syndrome: A case control study

With metformin alone the viable pregnancy rate was 34.28% (12 cases); rate of spontaneous abortion was 08.57% (3 cases); no cases of multiple pregnancy and OHSS found.

STUDY ON OVULATION INDUCTION WITH CLOMIPHENE CITRATE, METFORMIN, HUMAN CHORIONIC GONADOTROPIN AND HUMAN MENOPAUSAL GONADOTROPIN IN FEMALE INFERTILITY

Signs and symptoms of OHSS are hypovolemia, and metabolic and thromboembolic complications, which are mainly observed in severe OHSS cases needing hospitalization.

Substantial Effect of Fenugreek Seeds Aqueous Extract on Serum Estradiol Level in Ovarian Hyperstimulation Syndrome Rat Model

GnRH antagonist administered twice the day before hCG trigger combined with a step-down protocol may prevent OHSS in IVF/ICSI antagonist cycles at risk for OHSS without affecting the reproductive outcomes : a prospective randomized control trial.

Cost-effectiveness of GnRH antagonist implementation on hCG injection day/hCG gununde GnRh antagonist yapmanin maliyet etkinligi

The other suggested factors that may act directly or indirectly on the development or severity of OHSS are angiotensin II, insulinlike growth factor, epidermal growth factor, transforming growth factor alpha and beta, basic fibroblast growth factor, platelet-derived growth factor, interleukin-1B, and interleukin-6.

Ovarian Hyperstimulation Syndrome: A Narrative Review of Its Pathophysiology, Risk Factors, Prevention, Classification, and Management

To our knowledge, this is the first report of undetectable AMH serum level and subnormal level of inhibin B in a patient with clinical condition of PCOS, who developed a moderate form of OHSS during ovarian stimulation.

UNDETECTABLE SERUM LEVELS OF ANTI-MULLERIAN HORMONE IN WOMEN WITH OVARIAN HYPERSTIMULATION SYNDROME DURING IN VITRO FERTILIZATION AND SUCCESSFUL PREGNANCY OUTCOME: CASE REPORT

In vitro maturation of oocytes is nowadays successfully used in patients who are diagnosed with polycystic ovary syndrome and in patients who are candidates for developing the OHSS in IVF programs with a high rate of clinical pregnancies [27].

FERTILITY PRESERVATION IN CANCER PATIENTS/OCUVANJE FERTILITETA KOD ONKOLOSKIH PACIJENATA

Herein, we report two cases of severe OHSS during spontaneous first trimester pregnancy in whom a FSHR gene mutation has been discovered by the genetic testing.

Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports

Thus, we believe that despite the use of strategies to minimise the risk of OHSS, such as the use of gonadotrophin-releasing hormone (GnRH) antagonists for pituitary suppression [21], IVM should still be viewed as an alternative treatment option for women with PCOS.

The Place of In Vitro Maturation in PCO/PCOS

He also noted that aiming for a high number of eggs (more than 15) can increase the risk of ovarian hyperstimulation syndrome (OHSS), a potentially serious complication of ovarian stimulation.

Are more eggs better in IVF?

Pathophysiology of the cysts is similar to ovarian hyperstimulation syndrome (OHSS); however, they can be differentiated by the fact that OHSS is iatrogenic, whereas HL is a spontaneous occurrence.