ovarian hyperstimulation syndrome

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ovarian hyperstimulation syndrome

iatrogenic development of ovarian hyperstimulation that occurs when the luteotropic effects of human chorionic gonadotropin are exaggerated in a cycle in which ovarian stimulation has been done as a component of infertility treatment. The human chorionic gonadotropin is administered exogeneously to trigger ovulation after gonadotropin stimulation. It is present endogenously after implantation. Syndrome includes, to varying degrees, abdominal distention, potentially massive ovarian enlargement, and third spacing of vascular volume. It can range from moderate discomfort to life-threatening ovarian enlargement and fluid shifts.

ovarian hyperstimulation syndrome

,

OHSS

A potentially life-threatening complication that may occur in women receiving drugs to stimulate ovulation. The acute onset occurs within the first week ovulation is induced and is characterized by marked cystic ovarian enlargement, ascites, hydrothorax, arterial hypotension, tachycardia, hemoconcentration, oliguria, sodium retention, hypernatremia, and in severe cases renal failure. The condition is usually mild if the diameter of the ovary is less than 8 cm; moderate if 8 to 12 cm; and severe if greater than 12 cm.

Treatment includes symptomatic therapy to maintain circulatory function, bedrest, a low-sodium diet, and diuretic therapy. The life-threatening possibility can be avoided with close monitoring and withholding of drugs if ovarian response becomes excessive.

ovarian hyperstimulation syndrome

Ovarian enlargement, the production of multiple ovarian cysts, increased capillary permeability with generalized oedema and intravascular fluid depletion, SHOCK, and sometimes even death. The syndrome, which is uncommon, is caused by gonadotropin medical treatment to stimulate ovulation. Rarely, it may occur spontaneously during pregnancy as a result of a mutation in the gene for the follicle-stimulating hormone receptor.
References in periodicals archive ?
However, after the failure of conventional attempts, the low costs, no OHSS risk and possibility of being repeated in a short time make IVM a tempting prospect for couples (1).
5% difference in moderate/severe OHSS per Golan OHSS criteria between the two groups, stratified by age, IVF center, and IVF/ICSI.
No case of severe OHSS was reported in either the PCOS or the non-PCOS group.
OHSS customers can access a full suite of standard reports, including detailed billing backup and performance maintenance, through the Verizon Enterprise Center, a secure, global online portal.
The HFEA says that undergoing two cycles of treatment exposes a woman to the risk of OHSS twice.
Increased awareness of the most common complication, OHSS, may prompt additional study to characterize predictors of this and other adverse events to inform the development of effective approaches necessary to decrease complications," they wrote (JAMA 2015;313:88-90).
International SOS is a perfect and complementary fit with Beacon OHSS, as both organizations' success is driven by a relentless focus on quality service.
Recruited teachers and support personnel in the OHSS shall receive incentives, monetary compensation, honoraria and would be trained in relevant programs.
Mild stimulation protocols aim to retrieve less than six to eight eggs; a standard stimulation should aim for 10-15 eggs, and we believe this is what is associated with the best IVF outcomes; when the egg number exceeds 20, the risk of OHSS becomes high," he said.
1,3,4) Five women have died from OHSS in the United Kingdom (U.