ovarian hyperstimulation syndrome

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ovarian hyperstimulation syndrome

iatrogenic development of ovarian hyperstimulation that occurs when the luteotropic effects of human chorionic gonadotropin are exaggerated in a cycle in which ovarian stimulation has been done as a component of infertility treatment. The human chorionic gonadotropin is administered exogeneously to trigger ovulation after gonadotropin stimulation. It is present endogenously after implantation. Syndrome includes, to varying degrees, abdominal distention, potentially massive ovarian enlargement, and third spacing of vascular volume. It can range from moderate discomfort to life-threatening ovarian enlargement and fluid shifts.
Farlex Partner Medical Dictionary © Farlex 2012

ovarian hyperstimulation syndrome

,

OHSS

A potentially life-threatening complication that may occur in women receiving drugs to stimulate ovulation. The acute onset occurs within the first week ovulation is induced and is characterized by marked cystic ovarian enlargement, ascites, hydrothorax, arterial hypotension, tachycardia, hemoconcentration, oliguria, sodium retention, hypernatremia, and in severe cases renal failure. The condition is usually mild if the diameter of the ovary is less than 8 cm; moderate if 8 to 12 cm; and severe if greater than 12 cm.

Treatment includes symptomatic therapy to maintain circulatory function, bedrest, a low-sodium diet, and diuretic therapy. The life-threatening possibility can be avoided with close monitoring and withholding of drugs if ovarian response becomes excessive.

Medical Dictionary, © 2009 Farlex and Partners

ovarian hyperstimulation syndrome

Ovarian enlargement, the production of multiple ovarian cysts, increased capillary permeability with generalized oedema and intravascular fluid depletion, SHOCK, and sometimes even death. The syndrome, which is uncommon, is caused by gonadotropin medical treatment to stimulate ovulation. Rarely, it may occur spontaneously during pregnancy as a result of a mutation in the gene for the follicle-stimulating hormone receptor.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
In the Gynecology and Obstetrics Clinic "Narodni Front" a case control study was conducted on 50 female patients with severe forms of OHSS in the period from January 2008 to March 2015.
With metformin alone the viable pregnancy rate was 34.28% (12 cases); rate of spontaneous abortion was 08.57% (3 cases); no cases of multiple pregnancy and OHSS found.
Signs and symptoms of OHSS are hypovolemia, and metabolic and thromboembolic complications, which are mainly observed in severe OHSS cases needing hospitalization.
GnRH antagonist administered twice the day before hCG trigger combined with a step-down protocol may prevent OHSS in IVF/ICSI antagonist cycles at risk for OHSS without affecting the reproductive outcomes : a prospective randomized control trial.
The other suggested factors that may act directly or indirectly on the development or severity of OHSS are angiotensin II, insulinlike growth factor, epidermal growth factor, transforming growth factor alpha and beta, basic fibroblast growth factor, platelet-derived growth factor, interleukin-1B, and interleukin-6.
To our knowledge, this is the first report of undetectable AMH serum level and subnormal level of inhibin B in a patient with clinical condition of PCOS, who developed a moderate form of OHSS during ovarian stimulation.
In vitro maturation of oocytes is nowadays successfully used in patients who are diagnosed with polycystic ovary syndrome and in patients who are candidates for developing the OHSS in IVF programs with a high rate of clinical pregnancies [27].
Herein, we report two cases of severe OHSS during spontaneous first trimester pregnancy in whom a FSHR gene mutation has been discovered by the genetic testing.
Thus, we believe that despite the use of strategies to minimise the risk of OHSS, such as the use of gonadotrophin-releasing hormone (GnRH) antagonists for pituitary suppression [21], IVM should still be viewed as an alternative treatment option for women with PCOS.
He also noted that aiming for a high number of eggs (more than 15) can increase the risk of ovarian hyperstimulation syndrome (OHSS), a potentially serious complication of ovarian stimulation.
Pathophysiology of the cysts is similar to ovarian hyperstimulation syndrome (OHSS); however, they can be differentiated by the fact that OHSS is iatrogenic, whereas HL is a spontaneous occurrence.