In the Gynecology and Obstetrics Clinic "Narodni Front" a case control study was conducted on 50 female patients with severe forms of OHSS
in the period from January 2008 to March 2015.
With metformin alone the viable pregnancy rate was 34.28% (12 cases); rate of spontaneous abortion was 08.57% (3 cases); no cases of multiple pregnancy and OHSS
Signs and symptoms of OHSS
are hypovolemia, and metabolic and thromboembolic complications, which are mainly observed in severe OHSS
cases needing hospitalization.
GnRH antagonist administered twice the day before hCG trigger combined with a step-down protocol may prevent OHSS
in IVF/ICSI antagonist cycles at risk for OHSS
without affecting the reproductive outcomes : a prospective randomized control trial.
The other suggested factors that may act directly or indirectly on the development or severity of OHSS
are angiotensin II, insulinlike growth factor, epidermal growth factor, transforming growth factor alpha and beta, basic fibroblast growth factor, platelet-derived growth factor, interleukin-1B, and interleukin-6.
To our knowledge, this is the first report of undetectable AMH serum level and subnormal level of inhibin B in a patient with clinical condition of PCOS, who developed a moderate form of OHSS
during ovarian stimulation.
In vitro maturation of oocytes is nowadays successfully used in patients who are diagnosed with polycystic ovary syndrome and in patients who are candidates for developing the OHSS
in IVF programs with a high rate of clinical pregnancies .
Herein, we report two cases of severe OHSS
during spontaneous first trimester pregnancy in whom a FSHR gene mutation has been discovered by the genetic testing.
Thus, we believe that despite the use of strategies to minimise the risk of OHSS
, such as the use of gonadotrophin-releasing hormone (GnRH) antagonists for pituitary suppression , IVM should still be viewed as an alternative treatment option for women with PCOS.
He also noted that aiming for a high number of eggs (more than 15) can increase the risk of ovarian hyperstimulation syndrome (OHSS
), a potentially serious complication of ovarian stimulation.
Pathophysiology of the cysts is similar to ovarian hyperstimulation syndrome (OHSS
); however, they can be differentiated by the fact that OHSS
is iatrogenic, whereas HL is a spontaneous occurrence.