FGFR1

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FGFR1

A gene on chromosome 8p12 that encodes fibroblast growth factor receptor-1, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR1 mutations are associated with inherited syndromes (e.g., Antley-Bixler syndrome, autosomal dominant Kallmann syndrome 2, Jackson-Weiss syndrome, osteoglophonic dysplasia and Pfeiffer syndrome), as well as myeloproliferative disorders and stem cell leukaemia lymphoma syndrome.
References in periodicals archive ?
Briefly, cells were collected at 24 h post OGD, washed using cold phosphate buffer saline, and resuspended in binding buffer.
After 24 h incubation, the cells were exposed to OGD condition for 8 h and treated with 30 [micro]M formononetin under reoxygenation condition for another 20 minutes.
Abbreviations HBMEC human brain microvascular endothelial cell line RASMC rat aortic smooth muscle cell SMCs smooth muscle cells OGD oxygen and glucose deprivation EPCs endothelial progenitor cells FBS fetal bovine serum
The second module will prepare Data Contributors to share information on the OGD platform.
OLISTOP OGD does not influence the dyestuffs or the fibre surface and therefore no changes of the level of fastness have to be feared.
Afirmar, sin mas precisiones, que el OGD es "financiado por la Comunidad Europea" (sic) es, insisto, enunciar una verdad a medias y confundir al lector.
Previous investigators, studying younger and predominantly male patients, have suggested that larger diameter endoscopes caused a greater degree of oxygen desaturation during OGD [1, 7].
In addition, OGD issued its filing decisions on whether a submitted application was sufficiently complete to allow a substantive review for nearly all ANDAs submitted last year within 60 days.
The PC12 cell cultures were subjected to OGD for 12 h by incubation in a deoxygenated glucose-free balanced salt solution.
He added that the apparatus is the Organization and Guidance Department, or OGD - it is Kim Jung Il's education as he rose through the ranks, and was full of his university friends, it added.
Open government data portal Talking about the ITA's efforts to encourage the OGD, Fatma Al Riyami, director operation excellence at ITA, said: "The OGD portal has been launched at the Official eGovernment Services Portal (Omanuna) www.