FGFR1

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FGFR1

A gene on chromosome 8p12 that encodes fibroblast growth factor receptor-1, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR1 mutations are associated with inherited syndromes (e.g., Antley-Bixler syndrome, autosomal dominant Kallmann syndrome 2, Jackson-Weiss syndrome, osteoglophonic dysplasia and Pfeiffer syndrome), as well as myeloproliferative disorders and stem cell leukaemia lymphoma syndrome.
References in periodicals archive ?
Abbreviations HBMEC human brain microvascular endothelial cell line RASMC rat aortic smooth muscle cell SMCs smooth muscle cells OGD oxygen and glucose deprivation EPCs endothelial progenitor cells FBS fetal bovine serum
Under a pilot program, OGD has received over 50 QbR submissions from more than 20 sponsors.
OGD was not aware of the continuing problems with funding priorities and funding levels in the CFDA that we had identified until we brought them to its attention during our review.
More important, the rates of alcohol and drug abuse (further facilitated by the decriminalization of drug use in Russia in 1991) increased geometrically, especially in the cities, and fueled the demand for things provided in illegal markets (Lee, 1994; OGD, 1996).
2] in astrocytes and OGD, which is a model of ischemia and associated with free radical production in SH-SY5Y cells (Guo et al.
According to the report, Jang said that Kim Jung Il had the OGD as his old boys' network, adding that Kim Jong-un may have friends in his Swiss school, but he has no one inside North Korea.
DFS is also a mechanism for OGD and OND to have access to reviews completed in either Office, thus allowing full access to all available information on approved drug products.
Most cells suffered OGD showed obvious cell body damage, swelling, and cellular debris.
OGD is continuing to increase its staff in anticipation of the regulatory challenge ahead; however, current department policy has taken the hiring responsibility out of the Center for Drug Evaluation & Research and placed it within HHS, potentially slowing down the process.
OGD-dependent decrease in evoked field potentials can be prevented by a proceeding short OGD event (preconditioning).