FGFR1

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FGFR1

A gene on chromosome 8p12 that encodes fibroblast growth factor receptor-1, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR1 mutations are associated with inherited syndromes (e.g., Antley-Bixler syndrome, autosomal dominant Kallmann syndrome 2, Jackson-Weiss syndrome, osteoglophonic dysplasia and Pfeiffer syndrome), as well as myeloproliferative disorders and stem cell leukaemia lymphoma syndrome.
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References in periodicals archive ?
OGD received 449 applications in fiscal 2003, 88 more than in the previous year.
With the changes, OGD will also be identifying key leadership posts and evaluating budget priorities and office space.
"The left side of the Yankees infield has more funding than the OGD," he remarked.
It also awarded a contract for a gas gathering network from Thamama C and F to link up with ADNOC's OGD in 1996.
She is expected to review FDA perspectives and priorities, including the activities of the OGD.
There is no question that this year's $10 million increase for OGD funding was desperately needed.
And to ensure that ready access to generics is maintained, both lawmakers called for increased funding for the Food and Drug Administration's office of generic drugs (OGD).
-- The Generic Pharmaceutical Association (GPhA) applauds recent action by the House of Representatives that would increase funding for the Food and Drug Administration's office of generic drugs (OGD).
Table-III: Frequency of different diseases in abnormal OGD findings.