POU2F2

(redirected from OCT2)
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POU2F2

A gene on chromosome 19q13.2 that encodes a transcription factor which regulates transcription in various tissues, in addition to activating immunoglobulin gene expression. It transcription transactivation by NR3C1, AR and PGR.
References in periodicals archive ?
In type 2 diabetes, polymorphisms associated with altered metformin response have been identified in the solute carrier family 22 (organic cation transporter), member 1 (SLC22A1), and solute carrier family 22 (organic cation transporter), member 2 (SLC22A2), genes (encoding the organic cation transporter 1 and 2 proteins, OCT1 and OCT2, respectively) and the solute carrier family 47, member 1(SLC47A1), gene (encoding the multidrug and toxin extrusion 1 protein [MATE1]).
Metformin is a superior substrate for renal organic cation transporeter OCT2 rather than hepatic OCT [1] .
The seven identified transporters are: the efflux transporters P-glycoprotein (P-gp, MDR1, ABCB1) and BCRP (ABCG2); organic cation transporter OCT2 (SLC22A2); organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8); and organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3).