POU2F1

(redirected from OCT1)
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POU2F1

A gene on chromosome 1q24.2 that encodes a ubiquitous transcription factor which binds to and activates the promoters of genes for small nuclear RNAs (snRNA), as well as for histone H2B and immunoglobulins. It modulates transcription transactivation by NR3C1, AR and PGR.
References in periodicals archive ?
Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients.
Possibly in cooperation with the trans-acting POU homeodomain protein Oct1, OBS play a role in regulating the promoter expression in genes such as Cdx4 in Xenopus laevis (ReeceHoyes et al.
In addition, thymoquinone has also been shown to increase the expression of various organic anion and cation transporters such as OAT1, OAT3, OCT1, and OCT2, which are necessary for the renal clearance of xenobiotic agents including toxins and commonly used drugs [140, 141].
Previous work in the lab of Dean Tantin, Ph.D., senior author and associate professor in pathology at the University of Utah, showed that the transcription factor Oct1 is required for 'poising' Il2, a gene important for immunity, in a state where it can be activated quickly if needed.
These lines of evidence indicate that the down-regulation of Oct1 and Oct-2 expression is not likely to be the mechanism by which IL-4 inhibits Nos2 gene transcriptional activity.
US federal government has been partially shutdown since Oct1 amid a budget standoff congressional Republicans and the White House.
Novel recent investigations for de novo CML patients have examined the validity of gene expression profiling, genetic polymorphisms, next-generation genomics, multidrug resistance genes (MDR, OCT1), fusion transcripts, and preexisting BCR-ABL kinase domain mutations (34), (35), (36), (37), (38), (39), (40), (41), (42), (43).
Oct1 regulates cell growth of LNCaP cells and is a prognostic factor for prostate cancer.
Transcription factor oct1: Plasticity and multiplicity of functions.
Dake et al., "Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3," Molecular Pharmacology, vol.