CDH11

(redirected from OB-cadherin)

CDH11

A gene on chromosome 16q21 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH11 is a so-called type-II (atypical) cadherin—which lacks a HAV cell adhesion recognition sequence specific to type-I cadherins—and is expressed in osteoblastic cell lines. It is upregulated during differentiation, suggesting a role during in bone development and maintenance.

Molecular pathology
Defects in CDH11 commonly occur in aneurysmal bone cysts and consist of a translocation t(16;17)(q22;p13) with USP6.
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References in periodicals archive ?
reported that, in Rb-deficient osteoblasts, the expression of E-cadherin and osteoblast-cadherin (OB-cadherin) is downregulated [115].
All CDH genes (n = 27) screened in this study include CDH1 (E-cadherin), CDH2 (N-cadherin), CDH3 (P-cadherin), CDH4 (R-cadherin), CDH5 (VE-cadherin), CDH6 (K-cadherin), CDH7 (cadherin 7), CDH8 (cadherin 8), CDH9 (T1-cadherin), CDH10 (T2-cadherin), CDH11 (OB-cadherin), CDH12 (N-cadherin 2), CDH13 (H-cadherin), CDH15 (M-cadherin), CDH16 (KSP-cadherin), CDH17 (LI-cadherin), CDH18 (cadherin 18), CDH20 (cadherin 20), PCDHGA12 (CDH21), CDH22 CDH23 CDH24 DCHS1 (CDH19, or CDH25), CDH26 DCHS2 (CDH27), CDHR3 (CDH28), and CDHR4 (CDH29).