SLCO1B3

(redirected from OATP8)

SLCO1B3

A gene on chromosome 12p12 that encodes a transporter which mediates Na+-independent uptake of organic anions—e.g., oestradiol, taurocholate, triiodothyronine, leukotriene C4, dehydroepiandrosterone sulfate, methotrexate and sulfobromophthalein.
 
Molecular pathology
Defects in SLCO1B3 are a cause of Rotor syndrome.
References in periodicals archive ?
Unconjugated BS are transported by the multispecific ATP- and [Na.sup.+]-independent basolateral uptake transporters, organic anion-transporting polypeptide 1B1 (OATP1B1, also termed OATP-C, OATP2, SLC21A6, or LST-1, encoded by SLCO1B1), and 1B3 (OATP1B3, synonyms OATP8, SLC21A8, or LST3, encoded by SLCO1B3) [4, 7, 8].
Sugiyama, "Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of [Na.sup.+]-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and OATP1B3 (OATP8)," Molecular Pharmaceutics, vol.
Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).