SLCO5A1

(redirected from OATP5A1)

SLCO5A1

A gene on chromosome 8q13.3 that encodes an organic anion transporter.
References in periodicals archive ?
We found significantly higher expression of OATP3A1, low expression of OATP1B3 and OATP2B1, and similar expression of OATP4A1 and OATP5A1 in liver cancer patient samples compared to levels in normal tissue samples (Figure 6(c)).
Among those, we selected, for the microarray and RNA-seq analyses, four PG transporters, ABCC1 (also known as MRP1), ABCC9 (also known as sulfonylurea receptor 2 [SUR2]), SLCO4C1 (also known as OATP4C1), and SLCO5A1 (also known as OATP5A1), because these have been shown to be differentially expressed in the uterine endometrium during early pregnancy [10,11].
Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue.
Organic Anion Transporting Polypeptide 5A1 (OATP5A1) in Small Cell Lung Cancer (SCLC) Cells: possible involvement in chemoresistance to satraplatin.
OATP Signature sequence OATP1A2 D T R W V G A OATP1B1 D S R [W.bar] V G A OATP1B3 D S R W V G A OATP1C1 D P Q W V G A OATP2A1 D P R W I G A OATP2B1 D P R W V G A OATP3A1 D P R W I G A OATP4A1 S P L W V G A OATP4C1 D P R W L G A OATP5A1 D P R F I G N OATP6A1 S P E W L W T OATP Signature sequence OATP1A2 W W F G F L OATP1B1 [W.bar] [W.bar] L [N.bar] F L OATP1B3 W W L G F L OATP1C1 W W L G Y L OATP2A1 W W L G L L OATP2B1 W W L G F L OATP3A1 W W G G F L OATP4A1 W W V G F L OATP4C1 W W I G F L OATP5A1 W W S G F L OATP6A1 W W I N F L
Transporters of the OATP family OATP5A1 and OATP6A1 are not characterized for their transport function yet.
On the other hand, we showed that some OATPs (OATP2A1, OATP3A1, OATP4A1, and OATP5A1) become upregulated in primary and metastatic liver cancer as compared to nonmalignant liver.
In normal breast tissue, OATP5A1 is located at the cell membrane of epithelial cells lining the milk ducts.
Haploinsufficiency of the gene coding for OATP5A1 together with that encoding the heparan sulfate 6-O-endosulfatase 1 acting as a regulator of numerous growth factors in skeletal embryonic development were found to cause a rare autosomal dominant disorder, the mesomeliasynostoses syndrome.
Hamilton, "Organic anion transporting polypeptide 5A1 (OATP5A1) in small cell lung cancer (SCLC) cells: possible involvement in chemoresistance to satraplatin," Biomarkers in Cancer, vol.