SLCO1A2

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SLCO1A2

A gene on chromosome 12p12 that encodes a solute transporter that mediates the Na+-independent transport of organic anions such as sulfobromophthalein and conjugated (taurocholate) and unconjugated (cholate) bile acids. It is selectively inhibited by naringin in grapefruit juice.
References in periodicals archive ?
Previous in vitro studies showed that green tea catechins such as EGCG inhibited the activities of OATP1A2 and OATP2B1 which are expressed in the apical side of the intestinal epithelium in human (Roth et al.
Because of the structure and size of MCs, active uptake into cells occurs via organic anion-transporting polypeptides (OATP/Oatp), as confirmed for liver-specific human OATP1B1 and OATP1B3, mouse Oatp1b2 (mOatp 1b2), skate Oatp 1d1, and the more widely distributed OATP1A2 expressed, for example, at the blood--brain barrier.
Bailey added that orange and apple juices also appear to contain naringin-like substances that inhibit OATP1A2.