, which serves to transport bile acids and toxins from the blood into the hepatocyte, decreases.
The transporter families of greatest clinical relevance within the hepatocyte include organic anion transporting polypeptides (OATPs
), organic cation transporters (OCTs), multidrug resistance proteins (MDRs), breast cancer resistance protein (BCRP), the bile salt export pump (BSEP), and multidrug resistance-associated proteins (MRPs) [82, 83].
(11) Additional data indicate that orange juice and apple juice could have similar effects on OATPs
The organic anion transporting polypeptides (OATPs
) are a family of membrane transport proteins capable of transporting an array of structurally diverse endogenous and xenobiotic compounds [1-3].
Balogh et al., "Characterization of Organic Anion Transporting Polypeptide (OATP
) expression and its functional contribution to the uptake of substrates in human hepatocytes," Molecular Pharmacology, vol.
Abbreviations: AUC, area under the time-plasma concentration curve; BCS, biopharmaceutical classification system; BDDCS, biopharmaceutics drug disposition classification system; CYP, cytochrome P450; GTE, green tea extract; EGCG, C-)-epigallocatechi n-3-gal late; OATP
, organic anion transporting polypeptide; P-gp, P-glycoprotein.
Since microglia express several P2X and P2Y receptors , the possible involvement of purinergic receptors in the TNF-[alpha]/IFN-[gamma]-induced dye coupling in microglia treated with oxidized-ATP (oATP
), an inhibitor of P2X receptors , was studied.
The performance of the OATP
model is good and slightly inferior to the one of the IMATP model forecasting arrival time at the immediate downstream stop.
Furthermore, monolayer models consisting of a double (and triple) transfect are now commercially available; for example, MDCK11 cells transfected with both OATP
(15) Furanocoumarines and active bioflavonoids present in GFJ are also inhibitors of OATP
and when ingested concomitantly, can reduce the oral bioavailability of the OATP
The enhancement on the hepatocyte phase following the administration of Eovist is a function of the organic anion transporting polypeptide (OATP
) in functioning liver cells.
Because of the structure and size of MCs, active uptake into cells occurs via organic anion-transporting polypeptides (OATP/Oatp), as confirmed for liver-specific human OATP1B1 and OATP1B3, mouse Oatp1b2 (mOatp 1b2), skate Oatp
1d1, and the more widely distributed OATP1A2 expressed, for example, at the blood--brain barrier.