SLCO1A2

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SLCO1A2

A gene on chromosome 12p12 that encodes a solute transporter that mediates the Na+-independent transport of organic anions such as sulfobromophthalein and conjugated (taurocholate) and unconjugated (cholate) bile acids. It is selectively inhibited by naringin in grapefruit juice.
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References in periodicals archive ?
OATP, which serves to transport bile acids and toxins from the blood into the hepatocyte, decreases.
The transporter families of greatest clinical relevance within the hepatocyte include organic anion transporting polypeptides (OATPs), organic cation transporters (OCTs), multidrug resistance proteins (MDRs), breast cancer resistance protein (BCRP), the bile salt export pump (BSEP), and multidrug resistance-associated proteins (MRPs) [82, 83].
(11) Additional data indicate that orange juice and apple juice could have similar effects on OATPs. (12)
The organic anion transporting polypeptides (OATPs) are a family of membrane transport proteins capable of transporting an array of structurally diverse endogenous and xenobiotic compounds [1-3].
Balogh et al., "Characterization of Organic Anion Transporting Polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes," Molecular Pharmacology, vol.
Abbreviations: AUC, area under the time-plasma concentration curve; BCS, biopharmaceutical classification system; BDDCS, biopharmaceutics drug disposition classification system; CYP, cytochrome P450; GTE, green tea extract; EGCG, C-)-epigallocatechi n-3-gal late; OATP, organic anion transporting polypeptide; P-gp, P-glycoprotein.
Since microglia express several P2X and P2Y receptors [3], the possible involvement of purinergic receptors in the TNF-[alpha]/IFN-[gamma]-induced dye coupling in microglia treated with oxidized-ATP (oATP), an inhibitor of P2X receptors [53], was studied.
The performance of the OATP model is good and slightly inferior to the one of the IMATP model forecasting arrival time at the immediate downstream stop.
Furthermore, monolayer models consisting of a double (and triple) transfect are now commercially available; for example, MDCK11 cells transfected with both OATP and BCRP.
(15) Furanocoumarines and active bioflavonoids present in GFJ are also inhibitors of OATP and when ingested concomitantly, can reduce the oral bioavailability of the OATP substrate, fexofenadine.
The enhancement on the hepatocyte phase following the administration of Eovist is a function of the organic anion transporting polypeptide (OATP) in functioning liver cells.
Because of the structure and size of MCs, active uptake into cells occurs via organic anion-transporting polypeptides (OATP/Oatp), as confirmed for liver-specific human OATP1B1 and OATP1B3, mouse Oatp1b2 (mOatp 1b2), skate Oatp 1d1, and the more widely distributed OATP1A2 expressed, for example, at the blood--brain barrier.