GPR143

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GPR143

A gene on chromosome Xp22.3 that encodes a protein which binds to heterotrimeric G proteins, is targeted to melanosomes in pigment cells and is involved in melanosome biogenesis, organisation and transport. GPR143’s ligand-dependent signalling occurs through a G(q)-mediated pathway in melanocytic cells. It is a receptor for tyrosine, L-DOPA and dopamine; after binding to L-DOPA, it stimulates Ca2+ influx into the cytoplasm, increasing secretion of the neurotrophic factor SERPINF1 and relocalising beta arrestin at the plasma membrane.

Molecular Pathology
GP143 mutation causes ocular albinism type 1 (Nettleship-Falls-type ocular albinism).
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References in periodicals archive ?
As can be seen, the SNI design code tends to underestimate the load-capacity of beams with no transverse reinforcement (Beams OA1, OA2, and OA3).
"This is the reason Green OA1 mandates are the highest priority.
(See Table OA1 in the Supplementary Material for robustness checks against reverse causation.)
The contract will involve the award of a contract for works concerning the demolition and reconstruction of the structure known as Oa1 - a structure crossing the Foron at Gaillard (74) at the end of the street Of Geneva at the level of the Franco-Swiss Customs of Mollesulaz, within the framework of the implementation of phase 1 of the extension of a tramway line between Mollesulaz (Gaillard) - rue du Parc (Annemasse) About 2 kilometers.
The purpose of this contract is to construct the structure 1 (OA1) adjacent to the existing structure allowing the demolition of the existing platform and the preparation for the installation of a new platform on the existing structure Of the CHU bridge and the creation of a widening on the structure to provide a pedestrian path with a free passage of 1.80 m.
Deviation of Allain - road restoration work of Crepey Oa1 OA2 and wildlife restoration work.
Contract award: 15m0025-rd612 - deviation puisserguier structures oa1 and oa 3.
the Public Construction Oa1 Recovery RD14 and RD100, PIPO kind of shallow footings (underpass open portico) is built in the context of the completion of road deviation Saulx (70).
Contract notice: Rd612 - deviation puisserguier structures oa1 and oa 3
Contract award: rd 2 - doubling the work of art on the durance - town of cavaillon - connections works oa1 and oa2 existing channels.
creating routes connections from OA1 works (crossing the Durance) and OA2 (work schedule right bank) to existing roads and a roundabout 25 m outer radius on the right bank (Cavaillon).
Contract award: oa1 - works railway bridge hyeres pk 10473.