O3FAR1A gene on chromosome 10q23.33 that encodes a member of the rhodopsin family of G protein-coupled receptors that is a receptor for medium- and long-chain free fatty acids. O3FAR1 mediates a robust anti-inflammatory response, especially in macrophages and fat cells, by inhibiting TAK1 through a beta-arrestin 2 (ARRB2/TAB1)-dependent effect but independent of the G(q)/G(11)-coupled pathway. O3FAR1 mediates potent insulin-sensitising and antidiabetic effects by repressing macrophage-induced tissue inflammation.
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