Adjunctive aripiprazole, olanzapine, or quetiapine for major depressive disorder: an analysis of number needed to treat, number needed to harm
, and likelihood to be helped or harmed.
Evidence on number needed to treat and number needed to harm
(if available) from systematic reviews of respiratory tract infections is presented graphically in Fig.
Calculating number needed to treat (NNT) or number needed to harm
(NNH) does not tell you whether the result is statistically significant.
The number needed to treat for nonfatal MI was 162, compared to the number needed to harm
for nontrivial bleed of 73.
In the internal cohort crossover analysis - that is, analyzing outcomes before and after treatment in the same population - the differences in incidence did not reach statistical significance, making the estimated number needed to harm
She concluded by citing another study that showed that the number of children needed to treat with antidepressants to achieve one remission is 10, while the comparable number needed to harm
due to suicidal ideation or attempts is 112 (JAMA 2007;297:1683-96).
Another useful measure is the number needed to harm
That means the number needed to harm
is about 9,000 patients, which when combined with the possible risk of developing other lymphomas, the number needed to harm
is about 6,000 young males for one lymphoma death per year, Dr.
9 cases per 1,000 patient-years with moderate-dose therapy), corresponding to a number needed to harm
of 498 per year," the investigators said.
The number needed to harm
with prolonged antibiotic treatment for death alone was 21; for NEC alone, 54; and for the combination outcome, 22.
0 more cases per 1,000 patient-years) giving the number needed to harm
with intensive vs.
The two approved treatments also have a number needed to harm
in single digits.