null allele

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null allele

A segment of DNA which is not known to encode a protein product.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

null allele

a form of a gene whose product is either absent at the molecular level, or is present but has no measurable phenotypic function. For example, in a heterozygote with INCOMPLETE DOMINANCE one gene form is a ‘null allele’ and is inactive, while the other allele is unable to compensate for the null allele and so produces an intermediate phenotype.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
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pCAF Associates with CIITA Acetylation Null Mutants. As pCAF acts in a dual way as both HAT and ubiquitin ligase, and as acetylation drives CIITA nuclear import, we next determined if acetylation of CIITA is necessary for CIITA ubiquitination mediated by pCAF.
Pulling a Ligase out of a "HAT": pCAF Mediates Ubiquitination of the Class II Transactivator
CBP1 null mutants (CBP1 [delta]) are unable to induce macrophage apoptosis and are avirulent in murine model of pulmonary infection [45,46].
Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival
To determine whether CK1.1 is essential for parasite survival, we generated a CK1.1 null mutant in L.
Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit
Fgfr1 null mutant embryos die during gastrulation and segmentation, while homozygous embryos of Fgfr2 knockout die before gonad formation (18, 19).
Role of postnatal expression of Fgfr1 and Fgfr2 in testicular germ cells on spermatogenesis and fertility in mice
Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice.
Using genetically engineered animal models in the postgenomic era to understand gene function in alcoholism
Residual guanosine 3', 5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.
Genetic components of stringent response in Vibrio cholerae
To make null mutant mice, it takes at least about one year from the construction of the targeting vector if there is no delay during the whole procedure from steps such as colony selection of ES cells, chimera production and confirmation of germ line transmission for the mice.
Recent progress in biotechnology-based gene manipulating systems to produce knock-in/out mouse models
Decreased ethanol sensitivity and tolerance development in gamma-PKC null mutant mice is dependent on genetic background.
Applications of Transgenic and Knockout Mice in Alcohol Research
1987); and the null mutant [Adh.sup.n1], which has an inactive alcohol dehydrogenase (ADH) enzyme, was used for in vivo experiments (Grell et al.
A multilevel approach to the significance of genetic variation in alcohol dehydrogenase of Drosophila
In contrast, a loss-of-function mutant of SCM3, fc1, and another SL synthesis null mutant, d10, (42) exhibited not only desirable SL-related phenotypes (increased tiller number) but also unfavorable reduction in culm diameter and thickness.
Engineering the lodging resistance mechanism of post-green revolution rice to meet future demands
lin-11 null mutant animals display cryophilic defects that phenocopy laser ablation of the AIZ interneuron.
A common theme for LIM homeobox gene function across phylogeny?
(68) gon-1 null mutants show a number of severe phenotypes, including sterility, but we also found that certain genes, if downregulated, suppress even such severe phenotypes (Yoshina et al., in preparation).
Comprehensive functional genomics using Caenorhabditis elegans as a model organism

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