nucleoside

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nucleoside

 [noo´kle-o-sīd]
any of a class of compounds produced by hydrolysis of nucleotides, consisting of a sugar (a pentose or a hexose) and a purine or pyrimidine base.

nu·cle·o·side (Nuc, N),

(nū'klē-ō-sīd'),
A compound of a sugar (usually ribose or deoxyribose) with a purine or pyrimidine base by way of an N-glycosyl link.

nucleoside

/nu·cleo·side/ (noo´kle-o-sīd″) one of the compounds into which a nucleotide is split by the action of nucleotidase or by chemical means; it consists of a sugar (a pentose) with a purine or pyrimidine base.

nucleoside

(no͞o′klē-ə-sīd′, nyo͞o′-)
n.
Any of various compounds, such as adenosine or guanosine, that consist of a sugar, usually ribose or deoxyribose, linked to a purine or pyrimidine base. Nucleosides are constituents of the nucleotides that make up nucleic acids.

nucleoside

[no̅o̅′klē·əsīd′]
a component of a nucleotide that consists of a nitrogenous base linked to a pentose sugar.

nu·cle·o·side

(nū'klē-ō-sīd)
A compound of a sugar (usually ribose or deoxyribose) with a purine or pyrimidine base.

nucleoside

A molecule compounded of a purine or pyrimidine base attached to a sugar (ribose or deoxyribose). The genetic code in DNA and RNA depends on the order of the nucleosides. A nucleoside is a NUCLEOTIDE without the phosphate group.

nucleoside

a chemical compound in which a nitrogenous base is attached to a sugar. Such a structure occurs in DNA nucleotides where a phosphate group is attached to the deoxyribose sugar of the nucleoside.

nu·cle·o·side

(nū'klē-ō-sīd)
A compound of a sugar (usually ribose or deoxyribose) with a purine or pyrimidine base.

nucleoside (noo´klēəsīd´),

n purine or pyrimidine bases attached to a ribose or deoxyribose.

nucleoside

any of a class of compounds produced by hydrolysis of nucleotides, consisting of a sugar (a pentose or a hexose) and a purine or pyrimidine base.
References in periodicals archive ?
Salvage uptake of extracellular nucleosides via NTs is a key mechanism by which cells can circumvent the cytotoxic effects of inhibitors of de novo nucleotide synthesis, such as 5-FU, methotrexate, lometrexol and pemetrexed (Smith et al.
We discovered the structure of the transporter molecule, and now we believe it is possible to improve nucleoside drugs to be better recognized by a particular form of the transporter molecule that resides in certain types of tissue.
5) Because of the DAD report,(1) SMART investigators measured rates of MI, major cardiovascular disease, and an even broader group of cardiovascular diseases in three groups from the trial's continuous-therapy group: (1) people who took Ziagen without Videx, (2) people who took Videx, and (3) people who took other nucleosides.
Our findings suggest that the efavirenz plus two nucleosides was the best of the three approaches as initial therapy, even in patients with relatively advanced HIV disease," she said.
Nucleoside Analogue Reverse Transcriptase Inhibitors Generic Name Initials Trade Name Manufacturer Didanosine (1990) ddl Videx Bristol-Myers Squibb Lamivudine (1995) 3TC Epivir Glaxo Wellcome Stavudine (1994) d4T Zerit Bristol-Myers Squibb Zalcitabine (1992) ddC HIVID Hoffmann-LaRoche Zidovudine (1987) AZT/ZDV Retrovir Glaxo Wellcome Table 2.
Some companies developing nucleosides seem interested.
The poster (#1611 Patti, et al), entitled "Pharmacological Properties and In Vitro Characterization of INX-189, a Liver Targeted Phosphoramidate Nucleoside Analogue Inhibitor of NS5b" will be presented in the HCV Therapy: Preclinical and Early Clinical Development session from 8:00 am - 1:00 pm on Tuesday, November 3rd, 2009.
Although the effect has been associated with both nucleoside analogue reverse transcriptase inhibitors (NRTI) and protease inhibitors, not all of the drugs in both classes are equal in this regard, prompting investigators to consider new combinations that might have more favorable effects on fat distribution.
Tenofovir's efficacy may make it an attractive option for initial therapy because its safety profile appears to be better than commonly used nucleoside drugs.
Researchers at Mitsubishi Kasei Institute of Life Sciences in Tokyo and Tohoku University in Sendai identified the catalytic agent as 5-hydroxycytidine, a modified form of one of the four basic nucleoside building blocks making up every RNA chain.
CHARACTERIZATION OF A SERIES OF HIGHLY POTENT PHOSPHORAMIDATE NUCLEOSIDE ANALOGUE INHIBITORS OF HEPATITIS C POLYMERASE -
In addition, ZDV and 3TC caused fewer adverse effects than combinations with different nucleoside reverse transcriptase inhibitors, didanosine (ddI) and stavudine (d4T).

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