Nucleoside analogues


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Nucleoside analogues

The first group of effective anti-retroviral medications. They work by interfering with the AIDS virus' synthesis of DNA.
Mentioned in: AIDS
References in periodicals archive ?
Chemists and pharmacists here explore some of the techniques used to synthesize nucleoside analogues.
BOSTON -- Recent use of the nucleoside analogues abacavir and didanosine is associated with a significantly increased risk of myocardial infarction in HIV-infected individuals, whereas treatment with the thymidine analogues appears to convey no such risk, according to findings presented at the 15th Conference on Retroviruses and Opportunistic Infections.
An increase of lactic acid in the blood (lactic acidosis), which can cause death, has been reported in patients taking REYATAZ with other anti-HIV medicines called nucleoside analogues.
Approved March 14, 1996 for use alone or in combination with nucleoside analogues for the treatment of HIV infection in adults.
In addition to the protease inhibitors and the nonnucleoside reverse transcriptase inhibitors (or NNRTIs), new and more powerful second-generation nucleoside analogues (such as lamivudine-3TC) are now also available.
Initial treatment regimens for chronic HBV consist of monotherapy with interferon-[alpha], pegylated interferon-[alpha], or nucleoside analogues.
Severe lactic acidosis is an infrequent, but well-described complication of the class of HIV drugs known as nucleoside analogues.
31 per 100 patient-years in 55 patients treated with antiretroviral nucleoside analogues and a mortality of 7.
This combination product should only be used by those whose treatment regimens would otherwise include these doses of these three nucleoside analogues.

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