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Chemical glycosylation via DNPy-glycosides having an [beta]-C=N moiety (in red) directly prepared by using the nucleophilicity of hemiacetal.
5-7) The aim of this work was to prepare hyperbranched polyesters bearing amine groups of low nucleophilicity due to H-bonding.
The ionization of these sulfhydryl groups, and therefore the corresponding nucleophilicity, is determined by proton shuttling that occurs among basic (histidine, arginine, lysine) and acidic (aspartate, glutamate) amino acid residues that are brought into proximity via the tertiary structure of the protein, for example, the [arginine.
This was probably because diethyl malonate has low nucleophilicity in acidic media.
The activation is provided by the enhanced nucleophilicity of the sulfur atom.
The high rate of activated anionic polymerization is due to the fact that both reacting species are chemically activated and hence highly reactive: the lactam anion from the catalyst represents an activated monomer with increased nucleophilicity and then terminal N-acylated lactam unit from the activator presents an activated end group (growth centre) with increased acylaling ability.
Nucleophilicity of the polymerizing media is very important, as more nucleophilic solvent will react with free radical intermediates of the polymers and result in passive polymer films, whereas EMIPFSI is extremely hydrophobic, so it will facilitate the formation of ordered polymer with high doping level.
However, in all these strategies synthesis of this scaffold is problematic due to the limited nucleophilicity of aromatic amines [24-31].
In order increase the stability of compound and to reduce the nucleophilicity of sulphur atom in N-S bond, the sulfenamides were derived from thiophenol in which sulphur atom is directly attached to the phenyl group.
DMAP was added as Lewis base to enhance the nucleophilicity of the hydroxyl groups of the dextran polymers to form 3-methacryloyl-l-glyceryl ether of dextran (27).
Without study of the kinetics of polymerization, it is difficult to speak about the rate and rate constants of a reaction, nevertheless, it is reasonable to suppose that the nucleophilicity of phenol is the dominating force of this reaction.