nucleophile

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nucleophile

 [noo´kle-o-fīl″]
an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles). adj., adj nucleophil´ic.

nu·cle·o·phil

, nucleophile (nū'klē-ō-fil', -fīl),
1. The electron pair donor atom in a chemical reaction in which a pair of electrons is picked up by an electrophil; any reagent or substance that is attracted to a region of low electron density.
2. Relating to a nucleophil. Synonym(s): nucleophilic (1)
[nucleo- + G. philos, fond]

nucleophile

/nu·cleo·phile/ (noo´kle-o-fīl) an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles).nucleophil´ic

nu·cle·o·phil

, nucleophile (nū'klē-ō-fil, -fīl)
1. The electron pair donor atom in a chemical reaction in which a pair of electrons is picked up by an electrophil.
2. Relating to a nucleophil.
Synonym(s): nucleophilic (1) .
[nucleo- + G. philos, fond]

nucleophile

an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles).
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References in periodicals archive ?
However, these materials still contain the monomer sequences sensitive to nucleophilic attack seen before and consequently satisfactory results cannot be obtained under very aggressive conditions.
However, they probably still contain the sequence (3) which is know to be less susceptible to nucleophilic attack (ref.
The increased positive character of the H-bonded carbonyl promotes nucleophilic attack.
The chemoselectivity of the esterification reaction was attributed to the H-bond withdrawing electrons from the carbonyl, thereby promoting the nucleophilic attack by an OH group.
2] adduct is probably initiated by a nucleophilic attack involving carbon-5 of TBA onto carbon-1 of MDA, followed by dehydration and a similar reaction of the intermediate MDA-TBA adduct with a second molecule of TBA [15].
49) The electrophilic character of the carbon therefore significantly enhances its susceptibility to nucleophilic attack by electron-rich reagents.
In the case of "chemical nucleation" [9, 10], the enhanced crystallization rate was attributed to nucleophilic attack of nucleant on the carbonate group, which severely degraded PC and reduced the melt viscosity.
This structure is responsible for the last nucleophilic attack of the epoxy ring.
This can be interpreted in terms of the intermolecular transition state: according to this mechanism (23), strong hydrogen-bonding species, such as acid and alcohols, stabilize the transition state and encourage the nucleophilic attack of amine.
The esterification of acids with alcohols is a reversible reaction with a well-known mechanism (1, 2) Two reaction mechanisms through a tetrahedral intermediate and acyl-oxygen cleavage BAc-2 and AAc-2 are most common and require a nucleophilic attack of a hydroxylic nucleophile on the carbonyl double bond of the carboxylic or protonated carboxylic group.