nucleophile

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nucleophile

 [noo´kle-o-fīl″]
an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles). adj., adj nucleophil´ic.

nu·cle·o·phil

, nucleophile (nū'klē-ō-fil', -fīl),
1. The electron pair donor atom in a chemical reaction in which a pair of electrons is picked up by an electrophil; any reagent or substance that is attracted to a region of low electron density.
2. Relating to a nucleophil. Synonym(s): nucleophilic (1)
[nucleo- + G. philos, fond]

nucleophile

/nu·cleo·phile/ (noo´kle-o-fīl) an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles).nucleophil´ic

nu·cle·o·phil

, nucleophile (nū'klē-ō-fil, -fīl)
1. The electron pair donor atom in a chemical reaction in which a pair of electrons is picked up by an electrophil.
2. Relating to a nucleophil.
Synonym(s): nucleophilic (1) .
[nucleo- + G. philos, fond]

nucleophile

an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles).
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References in periodicals archive ?
Reaction then proceeds by the nucleophilic attack of oxirane ring by the primary amine groups formed to result in crosslinked structure.
A selective nucleophilic attack of the anomeric hydroxy group to an electrophile is possible due to the stronger acidity of the hemiacetal.
Once the lid is displaced, the active site is more exposed to the solvent and Ser163 which is more likely to carry out the nucleophilic attack (Brzozowski et al.
Attack at positive carbon by alcohol (HBA): nucleophilic attack by hydroxyl group;
Therefore, we propose that the [alpha]-oxygenation (path A) proceeds as a result of a nucleophilic attack of the peroxide anion t-[BuOO.
Finally, the resulting polymer-bound metal sulfide completes the crosslink by nucleophilic attack on another polymer chain.
The nucleophilic attack of nitrogen atom of 2,4-dimethyl aniline (1) on electron deficient electrophilic sulfur atom of benzenesulfonyl chloride (2) rendered N-(2,4-dimethylphenyl) benzenesulfonamide (3) in the presence of alkaline aqueous Na2CO3 under dynamic pH control at 9.
The water oxygen is involved in nucleophilic attack to the carbonyl carbon of the peptide bond to form an intermediate with a tetrahedral carbon at the substrate carbonyl position.
We propose scheme 1, which illustrates that in Step I, lactide is coordinated with the stannous octoate via a nucleophilic attack of the hydroxyl group of OLLA, leading to the insertion of lactide into the metal-oxygen bond by rearrangement of the electrons.
1] is due to the formation of a carbonyl group by the nucleophilic attack of water molecules on pyrrole.
The reaction mechanism(scheme 4) is suggested to be initialized by a nucleophilic attack of Mn[O.