nuclear receptor


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nuclear receptor

Any of a “superfamily” of soluble (non-membrane-bound) receptors for a constellation of physiologically active compounds (ligands), such as retinoids, steroids, thyroid hormone, vitamin D, and hypolipidemic drugs. When nuclear receptors are activated by their cognate ligand, they form dimers, bind DNA and activate transcription of relevant primary target genes.
References in periodicals archive ?
In this report, we developed a new method for screening novel nuclear receptor agonists, and used it to identify new candidate ligands for FXR and RARs.
Cheng et al., "The androgen receptor recruits nuclear receptor corepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists," The Journal of Biological Chemistry, vol.
The aims of this volume are to describe a range of molecular, structural, and cell biological protocols currently used to investigate the structure-function of nuclear receptors (a superfamily of ligand- activated transcription factors that act principally to directly control patterns of gene expression) and to discuss experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases.
Earlier research conducted by investigators at Dana-Farber had identified peroxisome proliferator-activated receptor-gamma (PPARgamma), the nuclear receptor that regulates the growth and differentiation of fat cells.
Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism.
However, this is a novel modification of PPAR[gamma] protein and thus our comprehensive analysis of PTMs can be applied to find previously unidentified PTMs in PPAR[gamma] proteins and other proteins including nuclear receptors.
In addition to the nuclear receptor activity discussed above gut bacteria secrete [beta]-glucuronidase, an enzyme that deconjugates estrogens.
Further, the RXR, which has an important role in the nuclear receptor family, is involved in regulating the expression of target genes through the heterodimer with other nuclear receptors such as peroxisome proliferator-activated receptors (PPARs) and the VDR.
Androgens are known to exert their effects via androgen receptor (AR), which is a member of the nuclear receptor superfamily (Mangelsdorf et al., 1995).
The molecular signatures of PFOA (CAS#335-67-1) and its ammonium salt (CAS# 3825-26-1) were downloaded as well as data on several prototypical nuclear receptor activators: rifampicin (CAS#13292-461) for PXR, phenobarbital (CAS#57-30-7) for CAR, and DEHP (CAS#117-81-7) and MEHP (CAS#4376-20-9) for PPARs.
Wahli, "Transcriptional control of physiological and pathological processes by the nuclear receptor PPAR[beta]/[alpha]," Progress in Lipid Research, vol.
FXR can also downregulate the transcription of specific target genes indirectly via another nuclear receptor, the small heterodimer partner (SHP, the NR0B2 gene).

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