There was focal nuclear pleomorphism
, loss of polarity, and architectural complexity, thus was interpreted as high-grade dysplasia (H&E, 200x).
was seen in 21 (58.3%) cases and was semiquantitatively assessed to be mild in 7 (19.4%), prominent in 11 (30.6%) and marked in 3 (8.3%) cases.
(2,8) Features that have been associated with local or distant recurrence include high cellularity, mitotic activity, nuclear pleomorphism
, and necrosis.
STIC lesions exhibit histologic features of morphologic atypia (increased nuclear/cytoplasmic ratio, prominent nucleoli, increased proliferation with an intact basement membrane, variably stratified fallopian tube epithelium with nuclear pleomorphism
) and have evidence of TP53 mutations (J.
The characteristic cytomorphologic features noted correspond to the histologic features and include large polygonal to round cells with granular to flocculent cytoplasm, well defined cell borders, mild nuclear pleomorphism
, vesicular nuclei, perinuclear clearing, and small to indistinct nucleoli.
Moderate nuclear pleomorphism
(50 75% mat- ure cells).
Pathologic features include closely packed cells with scanty cytoplasm, nuclear pleomorphism
, high mitotic rate, and necrosis (10).
The extent of tubule formation, number of mitotic figures and degree of nuclear pleomorphism
are the important factors of MBR histological grading systems but several features like nuclear margin, chromatin pattern and nucleoli that are included in cytological grading are not of much importance in histopathological grading .
Malignancy can be identified on histology by increased cellularity, nuclear pleomorphism
, cellular atypia, necrosis, haemorrhage and 4 or more mitoses per 10 high-power microscopic fields.
Nevertheless, few studies have been directed to evaluate the nuclear size and its variability in the preneoplastic epithelium of PIN, although some authors have suggested that the cytologic atypia and nuclear pleomorphism
were more remarkable in the basal layer in comparison with the apical or columnar stratum of PIN lesions (Epstein, 1994).
Subsequently, the pathology community, to a large degree, emphasized too much the mitotic activity aspect of that article and overlooked somewhat that of the 6 fibrosarcomas, 2 had moderate and 4 marked nuclear pleomorphism
, in contrast to, on average, much less cytologic atypia in the cellular fibromas.
The spindle cells had moderate nuclear pleomorphism
and were separated by collagenous matrix.