nuclear hormone receptor


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nuclear hormone receptor

member of large family of intracellular molecules that act as ligand-activated transcription factors; all steroid and thyroid hormones and retinoic acid exert their effects through nuclear receptors. Member molecules that have no known ligand have been called orphan nuclear receptor.

DAX1

A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY.

Molecular pathology
DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
References in periodicals archive ?
Cooney, "Regulation of the nuclear hormone receptor nur77 in muscle: influence of exercise-activated pathways in vitro and obesity in vivo," Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.
(2009) showed that perinatal exposure to BPA altered early adipogenesis in the rat, which is mediated by peroxisome proliferator--activated receptor [gamma] (PPAR[gamma]), a nuclear hormone receptor whose dysregulation is involved in the onset of diabetes and obesity (Swedenborg et al.
Bardoni et al., "An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita," Nature, vol.
These observations identified the nuclear hormone receptor REV-ERB[alpha] as an anti-inflammatory receptor and a therapeutic target in inflammatory disease.
Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells.
In December 2011, Karo Pharma said it entered a research collaboration and licensing agreement with Pfizer the aim of which was to discover and develop compounds that inhibit the activity of the nuclear hormone receptor RORgamma, for treatment of autoimmune diseases.
GR is a member of the nuclear hormone receptor family of ligand-gated transcription factors.
The human pregnane X receptor (PXR) is a nuclear hormone receptor (NHR) that regulates the transcription of genes involved in xenobiotic metabolism and excretion.
The product is a first-in-class selective agonist to retinoic acid receptor alpha, a nuclear hormone receptor that regulates transcription.
Thus, because many PBDEs, including those not used in this study, are speculated to have nuclear hormone receptor activities, we plan to study their effects, particularly those of accumulative PBDE metabolites such as 6-HO-BDE-47, 5-HO-BDE-47, and 5'-HO-BDE-99 recently found in human blood (Athanasiadou et al.
* Differentiation: interleukin-1/toll NF-[KAPPA]B, nuclear hormone receptor, apoptosis, receptor phosphotyrosine phosphatase
The nuclear hormone receptor RORgamma is a novel target for the treatment of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and psoriasis.

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