nuclear hormone receptor

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nuclear hormone receptor

member of large family of intracellular molecules that act as ligand-activated transcription factors; all steroid and thyroid hormones and retinoic acid exert their effects through nuclear receptors. Member molecules that have no known ligand have been called orphan nuclear receptor.


A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY.

Molecular pathology
DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
References in periodicals archive ?
5] M), we judged the PBDEs and their metabolites to be positive for agonistic or antagonistic activity against that nuclear hormone receptor.
The new SwitchGear pathway sets utilize experimentally-validated luciferase reporter vectors to accurately quantify human promoter activity from complete sets of genes associated with inflammation, cholesterol biosynthesis, oncology, vascular biology, nuclear hormone receptor signaling, and many other important biological pathways.
Nasdaq:EXEL) today announced that it has signed an extension of the company's research collaboration agreement with Bristol-Myers Squibb Company (NYSE:BMY) to discover novel therapies targeted against the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders.
The research in Chapter 7 describes gene expression changes in both in vivo and in vitro rat liver cells treated with nuclear hormone receptor ligands.
Glitazones appear to act primarily through the activation of the nuclear hormone receptor, PPARgamma.
Binding of a peroxisome proliferator (ligand) to PPAR[Alpha] activates this nuclear hormone receptor.
is a biopharmaceutical company dedicated to the discovery, development, and commercialization of novel, selective, small molecule nuclear hormone receptor modulators targeting hormone pathways to address a myriad of unmet medical needs in men and women.
New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator.
Glitazones appear to act primarily through the activation of nuclear hormone receptor, PPARgamma.
antagonists called Selective Estrogen Receptor Covalent Antagonists (SERCAs) that inactivate the estrogen receptor by targeting a cysteine that is not present in other nuclear hormone receptors.
Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response.

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