Nubain


Also found in: Dictionary, Wikipedia.

Nubain

 [nu´bān]
trademark for a preparation of nalbuphine hydrochloride, an opioid analgesic.

nalbuphine hydrochloride

Nubain

Pharmacologic class: Opioid agonist-antagonist

Therapeutic class: Analgesic, adjunct to anesthesia

Pregnancy risk category C

Action

Binds to opiate receptors in CNS, inhibiting ascending pain pathways. This inhibition alters perception of and response to painful stimuli.

Availability

Injection: 10 mg/ml, 20 mg/ml

Indications and dosages

Moderate to severe pain

Adults: 10 mg/70 kg I.V., I.M., or subcutaneously q 3 to 6 hours p.r.n., up to 160 mg/day. Maximum for single dose is 20 mg.

Adjunct to balanced anesthesia

Adults: 0.3 mg to 3 mg/kg I.V. over 10 to 15 minutes, followed by maintenance dose of 0.25 mg to 0.50 mg/kg I.V. in single doses p.r.n.

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:

• increased intracranial pressure, head trauma, myocardial infarction, severe heart disease, respiratory depression, renal or hepatic disease, impaired ventilation, hypothyroidism, adrenal insufficiency, prostatic hypertrophy, emotional instability, alcoholism

• history of substance abuse or dependence

• pregnant or breastfeeding patients

• children.

Administration

Make sure emergency resuscitation equipment and naloxone (antidote) are available before starting therapy.

• For I.M. use, inject deep into large muscle mass; rotate injection sites.

• When giving I.V. for pain, infuse undiluted over 2 to 3 minutes into vein or I.V. line with compatible solution (such as dextrose 5% in water, normal saline solution, or lactated Ringer's solution).

Adverse reactions

CNS: dizziness, sedation, headache, vertigo

CV: hypertension, hypotension, tachycardia, bradycardia

EENT: miosis

GI: nausea, vomiting, dry mouth

Respiratory: dyspnea, respiratory depression

Skin: sweating, clammy skin

Other: hypersensitivity reactions including anaphylaxis

Interactions

Drug-drug. CNS depressants (including general anesthetics, MAO inhibitors, sedative-hypnotics, tranquilizers, tricyclic antidepressants): additive CNS effects

Drug-diagnostic tests. Amylase, lipase: increased levels

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: additive CNS and respiratory depression

Patient monitoring

• Monitor vital signs. Watch for respiratory depression and heart rate changes.

• Evaluate patient for CNS changes. Institute safety measures as needed to prevent injury.

Watch for hypersensitivity reactions, including anaphylaxis.

Patient teaching

• Instruct patient to change position slowly and carefully to avoid dizziness from sudden blood pressure decrease.

• Tell patient to avoid CNS depressants (including alcohol, sedative-hypnotics, and some herbs) for at least 24 hours after taking nalbuphine.

• Advise patient to consult prescriber before taking herbs.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, vision, and alertness.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

Nubain

(no͞o′bān′)
A trademark for the drug nalbuphine hydrochloride.

Nubain

a trademark for a synthetic opioid analgesic (nalbuphine hydrochloride), used as an adjunct to anesthesia.

Nubain®

Nalbuphine, see tthere.

Nubain

A brand name for the narcotic analgesic NALBUPHINE.
References in periodicals archive ?
were employed by DuPont Pharmaceuticals, which marketed nalbuphine under the trade name Nubain until 2001.
The paramedic said that when he noticed Mrs Williams coughing violently he stopped injecting the Nubain, leaving half in a syringe, and injected an antidote.
But as she emerges damp and round from the shower, she asks again, and the nurses bring in a shot of Nubain.
GWENT: Drug users in the Gwent area are being warned by police of the dangers of a heroin substance called Nubain, usually taken to treat heart attacks, but which is potentially fatal.
A post-mortem examination also revealed Prozac and larger quantities of ephedrine, a stimulant, and Nubain, an analgesic.
As well as cocaine, she was taking the anti-depressant Prozac, a diet pill, ephedrine, and a strong pain-killer, Nubain.
Clinical tests - done mostly on men - have suggested the kappa drugs, which include brand names Nubain, Stadol and Talwin, are inferior to the morphine-codeine drugs, and they are prescribed much less often to the millions of Americans who undergo surgery or painful medical treatments each year.
But his sister, Cherrie, said the suspect had been using shabu (methamphetamine hydrochloride) and Nubain, a regulated pain killer, for about two decades.
Paula Driscoll, 17, became addicted to Nubain, paying pounds 8 a day for the opium derivative which is an alternative to heroin.
The mom was given a second injection of Nubain at 10:30 PM as she was having difficulty staying on top of the contractions.
As well as the cocaine, a small trace of Prozac and larger quantities of ephedrine, a stimulant, and Nubain, an analgesic, were also found.
6 million in cash, 70 grams of 'shabu' worth P240,000, several ampules of the regulated pain killer Nubain, cellular phones, bladed weapons, flat screen televisions, pairs of rubber shoes, personal appliances, and several drug paraphernalia.