Norton-Simon hypothesis


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Norton-Simon hypothesis

(nōr'tŏn sī'mŏn),
hypothesis that a tumor is composed of populations of faster-growing cells, which are sensitive to therapy, and slower-growing, more resistant cells. Given that only therapy that completely eradicates all tumor cells will be curative, this is most likely to occur with sequential, non-cross-resistant regimens. The initial regimen must be effective enough to result in a low residual tumor burden and is followed by one or more non-cross-resistant treatments to eradicate the remainder of the cancer.

Norton,

Larry, 20th century U.S. oncologist.
Norton-Simon hypothesis - a tumor is composed of populations of faster growing cells, which are sensitive to therapy, and slower growing, more resistant cells.

Simon,

Richard, 20th century U.S. oncologist.
Norton-Simon hypothesis - see under Norton, Larry