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Related to Norplant: Implanon




Norplant is a long-acting hormone that is inserted under the skin and prevents conception for up to five years. Depo-Provera is also a hormone, but is administered by intramuscular injection and provides protection against pregnancy for three months. Lunelle is another injectable contraceptive that is administered monthly (every 28 to 30 days); it was approved by the Food and Drug Administration (FDA) in October 2000. The hormone in Norplant and Depo-Provera is progestin, a synthetic hormone similar to one found naturally in a woman's body; Lunelle contains the hormones progestin and estrogen.


The purpose of these hormones is to prevent pregnancy; they are about 99% effective in achieving this goal. No hormonal contraceptive methods provide protection from AIDS or other sexually transmitted diseases.
Depo-Provera and Lunelle are given as an injection and work in several ways to prevent conception. First, the egg (ovum) is prevented from maturing and being released. The mucus in the cervix (opening into the uterus or womb) becomes thicker, making it difficult for the sperm to enter. Depo-Provera and Lunelle also cause the lining of the uterus to become thinner, making implantation of a fertilized egg unlikely.
An injection of Depo-Provera or Lunelle must be given within the first five days of a normal period. Depo-Provera provides protection against pregnancy for three months, while Lunelle provides similar protection for one month. Ovulation (release of a mature egg) typically occurs within 60 days of the last injection of Lunelle, about twice as fast after use of Depo-Provera. Also, because Lunelle is a combined hormone contraceptive as opposed to progestin-only Depo-Provera and Norplant, it is less likely to cause irregular or absent menstruation.
Norplant capsules contain a synthetic hormone that is slowly released over a period of up to five years. It functions like Depo-Provera in that it prevents the ovaries from producing ova (eggs) and also results in thicker mucus in the cervix, which prevents the sperm from passing through the cervix. Norplant can be inserted at any time.


The woman being considered for Depo-Provera or Lunelle will have a pelvic and breast examination, a Pap test (a microscopic examination of cell samples taken from the cervix), blood pressure check, weight check, and a review of her medical history. Women who have diabetes mellitus, major depression, blood clotting problems, liver disease, or weight problems should use these methods only under strict medical supervision. Depo-Provera or Lunelle should not be used if the woman is pregnant, has unexplained vaginal bleeding, suffers from severe liver disease, has breast cancer, or has a history of blood clots or stroke.
Individuals who select Norplant will receive the same basic physical examination. If approved for this method, a site of implantation will be selected (usually the inside of the upper arm), and the area prepared for minor surgery. The skin will be washed with soap and water, and an antiseptic, such as iodine solution, will be applied. The physician will use a local anesthetic to numb the area, a small incision will be made, the six Norplant capsules will be inserted, and the incision sewn up (sutured). Protection against pregnancy normally begins within 24 hours. If necessary, the implants can be removed in 15-20 minutes. Norplant should not be used by women who are pregnant, have blood clotting problems, or have unexplained vaginal bleeding. Advantages include light periods with less cramping and decreased anemia. This form of birth control may also be protective against endometrial cancer.
Because Depo-Provera and Norplant use only the hormone progestin, they may provide an alternative for women who can not use estrogen-containing birth control pills. One benefit of Lunelle, however, is that its effects wear off more quickly than Depo-Provera, an important factor in the event that a woman has serious side effects or wants to become pregnant.

Key terms

Hormone — A chemical produced in a gland or organ and transported by the blood to another area of the body where it produces a specific effect.
Pap test — A microscopic examination of cell samples taken from the cervix.


The most common side effects associated with Depo-Provera and Lunelle are yellowing of the skin, headache, nervousness, dizziness, abdominal pain, hair loss, rash, increase in the number of migraine headaches, increased or decreased interest in sexual intercourse, the development of dark spots on the skin, depression, and weakness. Danger signs that need to reported immediately include weight gain, heavy vaginal bleeding, frequent urination, blurred vision, fainting, severe abdominal pain, and coughing up blood. Because the effects of Depo-Provera may last up to 12 weeks, it may take a longer time for women trying to conceive to become pregnant after discontinuing the injections.
The main reactions to Norplant include headache, weight gain, irregular periods or no period at all, breast tenderness, acne, gain or loss of facial hair, color changes of the skin over the area of insertion, and ovarian cysts. The doctor should be notified immediately of lumps in the breast, heavy vaginal bleeding, yellowing of the skin or eyes, or infection of the incision. Women who use Norplant are discouraged from smoking.

Normal results

These hormone contraceptive methods normally result in a success rate of 99%.



"Depo Provera." Planned Parenthood of Western Washington.
"Is Depo-Provera For You?" Planned Parenthood Federation of America, Inc. 〈〉.
"Lunelle." Food and Drug Administration (FDA) Page.


trademark for a preparation of the contraceptivelevonorgestrel in the form of an implant that can be inserted beneath a woman's skin.
Insertion of Norplant capsules beneath the skin. From Nichols and Zwelling, 1997.


An implantable contraceptive system that prevents pregnancy by inhibiting ovulation and thickening the cervical mucus.
Adverse effects
Dysmenorrhea, headache, nervousness, nausea, vertigo, increased size of ovaries and fallopian tubes, dermatitis, acne, weight gain, breast tenderness, hirsutism.


Levonorgestrel Gynecology An implantable contraceptive that prevents pregnancy by inhibiting ovulation and thickening the cervical mucus Adverse effects Dysmenorrhea, headache, nervousness, nausea, vertigo, ↑ size of ovaries and fallopian tubes, dermatitis, acne, weight gain, breast tenderness, hirsutism. See Contraceptive.


A brand name for a now-withdrawn implantable long-term, reversible contraceptive containing LEVONORGESTREL. Some women may have Norplant in situ until the year 2005. Special precautions are necessary for their removal.
References in periodicals archive ?
In April 1986, its experts concluded that "suspension of the therapeutic research with Norplant was inappropriate," since "according to the Commission, no evidence was found of ethical lapses in the procedure utilized by the researchers, who respected the rules and spirit of the Brazilian Code of Medical Deontology, as well as international conventions relating to the matter" (23).
n the previous editorial we said that women on welfare should be encouraged, but not compelled, to use Norplant We suggested incentives, such as an additional benefit of some kind.
The aim of the present study was to analyze the factors that influence women's decisions to accept Norplant and to identify reasons for its early discontinuation.
For a patient who comes to the office to have Norplant capsules removed and has a contraceptive rod inserted at the same visit, CPT instructs you to report 11976 and 11981: Submit the claim as 11976, 11981-51 (Multiple procedures).
The negative press coverage of Norplant was so significant in the scientific and lay media that there is speculation it played a part in the decreased usage and eventual withdrawal of the medication from the market.
Insertion time is a mean of about 1 minute, compared with 4 minutes for the Norplant, Dr.
Insertion time is faster than the Norplant, about a mean of 1 minute, com pared with 4 minutes for the Norplant, The 4 cm-long, 2 mm-diameter Implanon rod is not radio-opaque.
The Implanon is much easier to insert and remove than the Norplant, and is very highly effective.
On the basis of two reports--a postmar-keting surveillance study of Norplant (Contraception 2001;63:187-209) and an international, multicenter, case-control study conducted by the WHO (Contraception 1998;57:315-24)--they conclude that there is "limited evidence" that progestin-only methods and combined injectable contraceptives do not increase the risk of VTE.
In the UK two main types are used, Norplant and Implanon.
plaintiffs brought a products liability suit alleging that they experienced multiple and severe side effects resulting from their use of the surgically implanted Norplant contraceptive.