Jazz Pharmaceuticals said solriamfetol (JZP-110) is a selective dopamine and norepinephrine reuptake inhibitor
(DNRI) in development for the treatment of excessive sleepiness in adult patients with narcolepsy, OSA, and Parkinson's disease.
Esbupropion is the S-enantiomer of bupropion, a dopamine and norepinephrine reuptake inhibitor
and nicotinic acetylcholine receptor antagonist which also serves to increase the bioavailability of dextromethorphan.
PARIS--Of patients with major depressive disorder who receive a selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor
(SNRI) as their initial pharmacotherapy, 40% do not achieve the minimum therapeutic dose within 4 weeks of diagnosis, according to a real-world study of U.
Strattera, a selective norepinephrine reuptake inhibitor
, is approved for both pediatric and adult patients.
Reboxetine (a-ariloxybenzyl derivative of morpholine) is a norepinephrine reuptake inhibitor
and also a norepinephrine transporter inhibitor, indicated in the therapy of unipolar depression, in panic and attention deficit hyperactivity disorders (4).
If SSRIs aren't effective, a serotonin and norepinephrine reuptake inhibitor
(SNRI) may be prescribed.
receptor, but also a serotonin and/or norepinephrine reuptake inhibitor
A third group took different antidepressants: venlafaxine (Effexor[R], a tetracyclic drug) and mirtazapine (Remeron[R], a serotonin norepinephrine reuptake inhibitor
, or SNRI).
Atomoxetine, a norepinephrine reuptake inhibitor
, was approved in 2002 as the first nonstimulant medication for attention-deficit/hyperactivity disorder (ADHD).
The drug, a selective serotonin norepinephrine reuptake inhibitor
(SNRI), has already been shown to be effective in relieving this bothersome menopausal symptom in a 12-week trial, which was reported last year.
It was reported yesterday that United States-based Sunovion Pharmaceuticals has submitted a new drug application to the US Food and Drug Administration for dasotraline, a novel investigational, dual-acting dopamine and norepinephrine reuptake inhibitor