noradrenaline reuptake inhibitor

(redirected from Norepinephrine reuptake inhibitor)
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noradrenaline reuptake inhibitor

One of a class of drugs that function by increasing the available amount of the neurotransmitter NORADRENALINE at synapses. This is achieved by interfering with the normal physiological reuptake mechanism that brings about the removal of noradrenaline from the synaptic gap. Selective noradrenaline reuptake inhibitors can have a useful antidepressive effect. They include AMITRIPTYLINE, CLOMIPRAMINE, DOXEPIN, IMIPRAMINE, AMOXAPINE, MAPROTILINE and NORTRIPTYLINE.
References in periodicals archive ?
Anything that affects serotonin levels works, she said, including venlafaxine (Effexor), a serotonin norepinephrine reuptake inhibitor.
The patients had to be quetiapine-naive and free of any antipsychotic, mood stabilizer, tricyclic antidepressant, or dopamine or norepinephrine reuptake inhibitor for 8 weeks before enrollment.
Bicifadine's main effect is as a serotonin and norepinephrine reuptake inhibitor with a moderate effect on dopamine reuptake inhibition, believed to be potentially complementary in treating neuropathic pain.
Bicifadine is a serotonin and norepinephrine reuptake inhibitor (SNRI).
XTL is developing Bicifadine, a serotonin and norepinephrine reuptake inhibitor, for the treatment of diabetic neuropathic pain, which is currently in a Phase 2b study.
Also presented were preclinical data on PSN602, an oral dual serotonin and norepinephrine reuptake inhibitor and 5-HT1A agonist, being developed for the treatment of obesity.
The norepinephrine reuptake inhibitor is now approved for continued treatment of ADHD in patients aged 6-15 years, based on new long term data, the company reported last month.
Atomoxetine, a norepinephrine reuptake inhibitor, was approved in 2002 as the first nonstimulant medication for attention-deficit/hyperactivity disorder (ADHD).
In late July, the FDA issued an approvable letter regarding reboxetine, a selective norepinephrine reuptake inhibitor, for the treatment of depression.
At a meeting of the FDA's pediatric advisory subcommittee last month, the panel agreed that the class labeling changes for the selective serotonin reuptake inhibitors (SSRIs) and for venlafaxine, a serotonin norepinephrine reuptake inhibitor (SNRI), were reasonable.
Cymbalta (duloxetine) a selective serotonin and norepinephrine reuptake inhibitor, indicated for depression, stress urinary incontinence and diabetic peripheral neuropathic pain.
today announced that it has completed patient randomization into its Phase 2b study of Bicifadine -- a serotonin and norepinephrine reuptake inhibitor (SNRI) -- for the treatment of diabetic neuropathic pain.