Treatment includes laser photocoagulation therapy for high-risk nonproliferative retinopathy
or proliferative retinopathy, or intravitreal injections of antivascular endothelial growth factor agents for central-involved diabetic macular edema.
The risk model was derived and tested based on data from 14,000 patients with no or mild nonproliferative retinopathy
treated in the Gloucestershire area.
Within 7-8 months after diagnosis, 14% already had nonproliferative retinopathy
By 2002 she developed nonproliferative retinopathy
In the study by Moss et al, proliferative retinopathy was detected in 135 patients (79%), nonproliferative retinopathy
in 32 (19%), and no retinopathy in 3 (2%).
The study population included patients in a primary intervention cohort who had diabetes for 1-5 years with an albumin excretion rate of less than 40 mg per 24 hours and no retinopathy and those in a secondary intervention cohort with a 1-to 15-year history of diabetes, an albumin excretion rate of 200 mg or less per 24 hours, and no more than moderate nonproliferative retinopathy
, he noted.
By the end of the study, intensive therapy had reduced the development of retinopathy by 76%, the progression of retinopathy by 54%, and the development of proliferative or severe nonproliferative retinopathy
by 47%, compared with conventional therapy.