Lobo, "Macular thickness measured by stratus optical coherence tomography in patients with diabetes type 2 and mild nonproliferative retinopathy
without clinical evidence of macular edema," Ophthalmologica, vol.
Although nonproliferative retinopathy
usually does not cause vision loss and not require treatment, macular edema must be treated.
Treatment includes laser photocoagulation therapy for high-risk nonproliferative retinopathy
or proliferative retinopathy, or intravitreal injections of antivascular endothelial growth factor agents for central-involved diabetic macular edema.
The risk model was derived and tested based on data from 14,000 patients with no or mild nonproliferative retinopathy
treated in the Gloucestershire area.
in 2006 observed less severe DR than expected, with a very low prevalence of moderate-severe nonproliferative retinopathy
(10%) and only one person was treated of PDR by 14 years' duration .
"Within 7-8 months after diagnosis, 14% already had nonproliferative retinopathy
. That number is similar to the amount found in the Diabetes Prevention Program study, for a population that was an average of 55 years old.
High blood sugar accelerates atherosclerosis, which can cause blockages in the tiny blood vessels in the eye (nonproliferative retinopathy
By 2002 she developed nonproliferative retinopathy
For example, based on data from Moss et al, Singer et al Calculated that "for the detection of proliferative retinopathy, ophthalmoscopy had a sensitivity of 0.79 and a specificity of 0.99 for 170 patients known to have proliferative retinopathy by seven-field stereoscopic retinal photography." In the study by Moss et al, proliferative retinopathy was detected in 135 patients (79%), nonproliferative retinopathy
in 32 (19%), and no retinopathy in 3 (2%).
The increased level of VEGF expression was found already in the early stages of nonproliferative retinopathy
in children and adolescents with T1DM [48-50].
The study population included patients in a primary intervention cohort who had diabetes for 1-5 years with an albumin excretion rate of less than 40 mg per 24 hours and no retinopathy and those in a secondary intervention cohort with a 1-to 15-year history of diabetes, an albumin excretion rate of 200 mg or less per 24 hours, and no more than moderate nonproliferative retinopathy
, he noted.
Furthermore, if retinopathy is manifested to some degree, the screening time should be reduced to half a year (in the case of nonproliferative retinopathy
) and three months (for preproliferative retinopathy).