non-alcoholic fatty liver disease

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non-alcoholic fatty liver disease

A fatty liver lacking histologic features typically associated with alcohol abuse, which primarily affects overweight women. With time, patients develop portal changes such as interface hepatitis, increased portal inflammation and fibrosis, and autoantibodies.
 
Risk factors
Diabetes, obesity, hypertension, gallstones, hyperlipidaemia, hypertriglyceridaemia.

Pathogenesis
Uncertain; possibly oxidative stress and lack of antioxidants.

Non-alcoholic fatty liver disease types
• Steatosis;
• Steatosis with inflammation;
• Non-alcoholic steatohepatitis (NASH);
• Cirrhosis.
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References in periodicals archive ?
Silymarin attenuated hepatic steatosis through regulation of lipid metabolism and oxidative stress in a mouse model of nonalcoholic fatty liver disease (NAFLD).
Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle- aged population utilizing ultrasound and liver biopsy: a prospective study.
Nonalcoholic fatty liver disease in Saudi type 2 diabetic subjects attending a medical outpatient clinic: prevalence and general characteristics.
Body mass index and risk of nonalcoholic fatty liver disease: Two electronic health record prospective studies.
'With the rise in childhood obesity, we are seeing more kids with nonalcoholic fatty liver disease in our pediatric weight management practice,' said Jennifer Woo Baidal, lead author of the paper.
Although she did have a diagnosis of nonalcoholic fatty liver disease, she had not progressed to cirrhosis of the liver.
Nonalcoholic fatty liver disease: from steatosis to cirrhosis.
The most common primary etiologies for cirrhosis are chronic hepatitis B, alcoholic liver disease, chronic hepatitis C, and nonalcoholic fatty liver disease (NAFLD) [2].
Jo et al., "PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes," Journal of Gastroenterology and Hepatology, vol.
Nonalcoholic fatty liver disease (NAFLD) is a multifactorial condition resulting from a complex interaction of genetic and environmental factors.
Nonalcoholic fatty liver disease (NAFLD) is the liver pandemic in this 21st century, affecting 20-45% population around the world [1-5].