non-nucleoside reverse transcriptase inhibitors


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Related to non-nucleoside reverse transcriptase inhibitors: Protease inhibitors, Entry inhibitors, fusion inhibitors, Integrase inhibitors

Non-Nucleoside Reverse Transcriptase Inhibitors

 

Definition

This type of drug interferes with an enzyme that is key to the replication (reproduction) of the human immunodeficiency virus (HIV). The drug is designed to help suppress the growth of HIV, but does not eliminate it.

Purpose

This medication is used to treat patients with the HIV virus and AIDS in combination with one or more other AIDS drugs. Combining NRTIs with older drugs improves their ability to lower the levels of HIV in the bloodstream, and strengthens the immune system.
HIV becomes rapidly resistant to this class of drugs when they are used alone. However, in combination with older drugs, they can interfere with the virus's ability to become resistant because they attack the virus on several fronts. As the virus tries to evade one drug, another attacks. This combination can lower the level of HIV in the blood to undetectable levels.

Precautions

Patients should not discontinue this drug even if symptoms improve without consultation with a physician.

Description

Nucleoside analogues, the first class of HIV drugs to be developed, worked by incorporating themselves into the virus's DNA, making the DNA incomplete and therefore unable to create a new virus. Non-nucleoside inhibitors work at the same stage as nucleoside analogues, but act in a completely different way, preventing the conversion of RNA to DNA.
This class of drugs includes nevirapine (Viramune) and delavirdine (Rescriptor). It may take several weeks or months before the full benefits are apparent.
Depending on the drug prescribed, doses may start with a lower amount and be increased after a short period of time.

Risks

A mild skinrash iscommon; a severeskin rashcan be a life threatening reaction. Other possible side effects include fever, blistering skin, mouth sores, aching joints, eye inflammation, headache, nausea, and tiredness.
Because the drug passes into breast milk, breastfeeding mothers should avoid the drug, or not nurse until the treatment is completed.

Resources

Organizations

National AIDS Treatment Advocacy Project. 580 Broadway, Ste. 403, New York, NY 10012. (888) 266-2827. http://www.natap.org.

Key terms

Human immunodeficiency virus (HIV) — The virus that causes AIDS.

non-nucleoside reverse transcriptase inhibitors

NNRTIs, drugs used to treat HIV infections in combination with other drugs. Examples are efavirens (Sustiva) and nevirapine (Viramune).
References in periodicals archive ?
Efavirenz is the non-nucleoside reverse transcriptase inhibitor of choice with rifampicin.
They recorded the incidence of myocardial infarction during the follow-up period and looked at the associations between myocardial infarction and exposure to protease inhibitors or non-nucleoside reverse transcriptase inhibitors.
Non-nucleoside reverse transcriptase inhibitors (non-nukes): These medications also block the viral reverse transcriptase but do so by directly binding to that enzyme (see #2 in diagram).
Our most advanced drug candidate is RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI), which is in a Phase 2a study for the treatment of HIV.
I believe in making it a friend, for example trying to induce hypersensitivity to non-nucleoside reverse transcriptase inhibitors (NNRTIs) by capitalizing on the maintenance of resistance to nucleoside agents.
Tibotec scientists also reported on the in vitro activity of a new investigational class of reverse transcriptase inhibitors that are believed to be different from nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Nevirapine (Viramune) is a member of a family of anti-HIV drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Current antiviral drug classes and targets: interferons (IFNs), pegylated IFNs, nucleoside analogues, nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), nucleoside polymerase inhibitors, non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors, CCR5 inhibitors, fusion inhibitors, integrase inhibitors, neuraminidase inhibitors, monoclonal antibodies (MAbs).
Gilead's Truvada is a highly potent, well-tolerated, convenient, once-daily fixed-dose combination of two non-nucleoside reverse transcriptase inhibitors.
However, these 25 patients, all of whom were naive to non-nucleoside reverse transcriptase inhibitors (NNRTIs), were given efavirenz (Sustiva), a potent NNRTI, in addition to Kaletra and nucleoside reverse transcriptase inhibitors (NRTIs).
In the United States, Truvada is indicated in combination with other antiretroviral agents (such as non-nucleoside reverse transcriptase inhibitors or protease inhibitors) for the treatment of HIV-1 infection in adults.
Investigators have demonstrated that a dual NRTI strategy provides clinical benefit, and it leaves the powerful protease inhibitors and non-nucleoside reverse transcriptase inhibitors available for later use, when your T cell count is lower and you need potent therapy.

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