noncompetitive inhibition

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inhibition

 [in″hĭ-bish´un]
1. arrest or restraint of a process.
2. in psychoanalysis, the conscious or unconscious restraining of an impulse or desire. adj., adj inhib´itory.
competitive inhibition inhibition of enzyme activity by an inhibitor (a substrate analogue) that competes with the substrate for binding sites on the enzymes.
contact inhibition inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
noncompetitive inhibition inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

non·com·pet·i·tive in·hi·bi·tion

a type of enzyme inhibition in which the inhibiting compound does not compete with the natural substrate for the active site on the enzyme but inhibits the reaction by combining with the enzyme-substrate complex as well as with the free enzyme.
Farlex Partner Medical Dictionary © Farlex 2012

non·com·pet·i·tive in·hi·bi·tion

(non'kŏm-pet'i-tiv in'hi-bish'ŭn)
A type of enzyme inhibition in which the inhibiting compound does not compete with the natural substrate for the active site on the enzyme, but inhibits the reaction by combining with the enzyme-substrate complex, after the latter has been formed, and with the free enzyme.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

noncompetitive inhibition

a form of enzyme control in which the enzyme has two kinds of ACTIVE SITE, one for an inhibitor, the other for the enzyme substrate. The inhibitor prevents catalytic activity of the enzyme, perhaps by locking or even changing the shape of the substrate active site. Compare COMPETITIVE INHIBITION. See also ALLOSTERIC ENZYME.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Segel, Non-Competitive Inhibition (Simple Intersecting Linear Non-Competitive Inhibition).
This effect was found to be a non-competitive inhibition. The non-competitive binding means zinc is binding on another transporter spatially distinct from the active site regardless of the presence of iron.
Non-competitive inhibition was also observed in acid phosphatses purified from seedlings of soybeans [2], but the enzyme was found insensitive to tartrate inhibition.
AUC-P and AUC-V addition results in a rightward and downward shift of the [Ba.sup.2+] curve which indicates a non-competitive inhibition (antispasmodic effect) of the [Ba.sup.2+] effect.
Donepezil is a piperidine-type cholinesterase inhibitor, which exerts reversible, non-competitive inhibition of acetylcholinesterase, being structurally distinct from the other cholinesterase inhibitors available today.