noncompetitive inhibition

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inhibition

 [in″hĭ-bish´un]
1. arrest or restraint of a process.
2. in psychoanalysis, the conscious or unconscious restraining of an impulse or desire. adj., adj inhib´itory.
competitive inhibition inhibition of enzyme activity by an inhibitor (a substrate analogue) that competes with the substrate for binding sites on the enzymes.
contact inhibition inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
noncompetitive inhibition inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.

non·com·pet·i·tive in·hi·bi·tion

a type of enzyme inhibition in which the inhibiting compound does not compete with the natural substrate for the active site on the enzyme but inhibits the reaction by combining with the enzyme-substrate complex as well as with the free enzyme.

noncompetitive inhibition

[-kəmpet′itiv]
(in pharmacology) a form of inhibition in which a substance (drug) occupying a receptor cannot be displaced from the receptor by increasing the number of other molecules through the principle of mass action. The drug is irreversibly bound to the receptor.

non·com·pet·i·tive in·hi·bi·tion

(non'kŏm-pet'i-tiv in'hi-bish'ŭn)
A type of enzyme inhibition in which the inhibiting compound does not compete with the natural substrate for the active site on the enzyme, but inhibits the reaction by combining with the enzyme-substrate complex, after the latter has been formed, and with the free enzyme.

noncompetitive inhibition

a form of enzyme control in which the enzyme has two kinds of ACTIVE SITE, one for an inhibitor, the other for the enzyme substrate. The inhibitor prevents catalytic activity of the enzyme, perhaps by locking or even changing the shape of the substrate active site. Compare COMPETITIVE INHIBITION. See also ALLOSTERIC ENZYME.

inhibition

arrest or restraint of a process.

competitive inhibition
inhibition of enzyme activity by an inhibitor (a substrate analog) that competes with the substrate for binding sites on the enzymes.
contact inhibition
inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
end-product inhibition
see feedback inhibition (below).
feedback inhibition
a common way of regulating enzyme activity in which the reaction product (or in the case of a biosynthetic pathway, the product of the reaction sequence) inhibits the enzyme activity. Called also end-product inhibition.
neurological inhibition
the intermittency of transmission of nervous impulses depends on variations in the balance between excitation and inhibition, the latter being either pre- or postsynaptic.
noncompetitive inhibition
inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.