Non-Hodgkin's lymphoma


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Non-Hodgkin's lymphoma (NHL)

[- hoj′kənz]
solid tumors of peripheral lymphoid tissue classified by histological features and lymphocyte morphology. Distinguished from Hodgkin's lymphoma, a proliferation of Reed-Sternberg cells with accumulation of reactive peripheral blood cells. Non-Hodgkin's lymphoma prevalence peaks at 50 years of age and may be mild or aggressively malignant, depending upon cell category. Once called lymphosarcoma or sarcoma.
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Non-Hodgkin's lymphoma

non-Hodgkins' lymphoma

A lymphoid cancer that is not Hodgkins disease: NHL ALL, B cell lymphoma, Burkitt's lymphoma, diffuse cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, lymphoblastic lymphoma, mantle cell lymphoma, mycosis fungoides, post-transplantation lymphoproliferative disorder, small non-cleaved cell lymphoma, T-cell lymphoma Epidemiology Incidence ↑ 8.5/105 in 1973→15/105 in 1990 (21/105, in 2000, Canada ♂), ±53,900 new cases/yr, US in 2002; 60% of all lymphomas are NHLs, of which 55% are diffuse, 45% are nodular Risk factors AIDS, primary immunodeficiency, immunosuppression, transplants, exposure to pesticides, hair dyes, smoking, alcohol, in older ♀–linked to ↑ consumption of meat/animal fats– Management Chemotherapy, especially CHOP Complications Spinal cord compression occurs in up to 10%, which is often aggressive, and may respond to high-dose RT. See Lymphoma, REAL classification, Working Formulation.
Non-Hodgkin's lymphoma
Stage I CA present in only one lymph node area or in only one extranodal regional/organ
Stage II CA present in ≥ 2 lymph node areas on same side of diaphragm; CA present in only one extranodal area or organ outside the lymph nodes and in the lymph nodes around it. Other lymph node areas on the same side of the diaphragm may also have cancer
Stage III CA present in lymphoid tissue on both sides of the diaphragm; tumor may also have spread to an area or organ near the lymph node areas and/or to the spleen
Stage IV CA has spread to > one organ or organs outside lymphoid tissue; CA has spread to only one organ outside the lymph system, but lymph nodes distant from that organ are involved

Non-Hodgkin's lymphoma

Cancer that originates in the lymphatic system and typically spreads throughout the body.
References in periodicals archive ?
Involvement of the thyroid and the salivary glands in childhood non-Hodgkin's lymphomas at initial diagnosis.
A case-control study of non-Hodgkin's lymphoma and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) in eastern Nebraska.
Non-hodgkin's Lymphoma Phase 1 Clinical Trial Pipeline Insights
The report provides estimates and forecasts of Non-Hodgkin's Lymphoma prevalence, Non-Hodgkin's Lymphoma diagnosis rate, and Non-Hodgkin's Lymphoma treatment rate for the period 2012-2019.
Anderson Cancer Center, said, "We are encouraged by the response seen with ATRAGEN in the treatment of non-Hodgkin's lymphoma in a difficult patient population who have failed prior therapy.
Biosource and Levy's group has already infected tobacco plants with antibody-fragment genes from people with non-Hodgkin's lymphoma.
GlobalData estimated the global Non-Hodgkin's Lymphoma (NHL) market to be worth $6.
So it's unclear whether the link between PCBs and non-Hodgkin's lymphoma traces to activation of the cell receptor where dioxins attach.
According to the American Cancer Society's California study of selected cancer sites (1974-1985), the five-year cancer survival rate for all stages of non-Hodgkin's lymphoma is approximately 50 percent.
The compound is in development by sanofi-aventis for the treatment of relapsed/refractory CD19-expressing non-Hodgkin's lymphoma and other B-cell malignancies.
researchers suggest that a diet heavy on steak and hamburger may increase the risk of non-Hodgkin's lymphoma, a cancer of the immune system.
Relapsed Non-Hodgkin's Lymphoma is currently treated with multi-agent chemotherapy regimens.