non-Hodgkin lymphoma

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non-Hodg·kin lym·pho·ma (NHL),

a lymphoma other than Hodgkin disease, classified by Rappaport into a nodular or diffuse tumor pattern and by cell type; a working or international formulation separates such lymphomas into low-, intermediate-, and high-grade malignancy and into cytologic subtypes reflecting follicular center cell or other origin.
Farlex Partner Medical Dictionary © Farlex 2012

non-Hodgkin lymphoma

(nŏn′hŏj′kĭn) or

non-Hodgkin's lymphoma

(-kĭnz)
n.
Any of a large group of lymphomas that can be slow-growing or fast-growing, involve malignancies of either B cells or T cells, and are typically distinguished from Hodgkin lymphoma by the absence of Reed-Sternberg cells. Symptoms include enlarged lymph nodes, fever, night sweats, and weight loss.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

non-Hodg·kin lym·pho·ma

(non-hoj'kin lim-fō'mă)
A lymphoma other than Hodgkin disease, classified by Rappaport into a nodular or diffuse tumor pattern and by cell type; a working or international formulation separates such lymphomas into low, intermediate, and high grade malignancy and into cytologic subtypes reflecting follicular center cell or other origin.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
Enlarge picture
NON-HODGKIN LYMPHOMA: Bizarre-appearing lymphocytes revealing active mitosis (orig. mag. ×1000)

non-Hodgkin lymphoma

Abbreviation: NHL
Any of a group of malignant tumors of B or T lymphocytes. In 2008, the American Cancer Society estimated that about 66,100 Americans would be newly diagnosed with the disease. See: illustration; Hodgkin disease

Symptoms

Painless lymphadenopathy in two thirds of patients is the most frequent presenting symptom. Others have fever, night sweats, and loss of 10% or more of body weight in the 6 months before presenting with symptoms of infiltration into nonlymphoid tissue. Additional involvement is in peripheral areas such as epitrochlear nodes, the tonsillar area, and bone marrow. NHL is 50% more frequent in occurrence in men than in women of similar age. In most cases the cause of NHL is unknown, but patients who have received immunosuppressive agents have an over 100 times greater chance of developing NHL, probably because the immunosuppressive agents activate tumor viruses.

Treatment

Specific therapy depends on the type, grade, and stage of the lymphoma. Combination chemotherapies, bone marrow transplantation, radiation therapy, and photochemotherapy may be given, depending on the specific diagnosis.

See also: lymphoma
Medical Dictionary, © 2009 Farlex and Partners

Hodgkin,

Thomas, English physician, 1798-1866.
Hodgkin disease - malignant neoplasm of lymphoid cells of uncertain origin, associated with inflammatory infiltration of lymphocytes and eosinophilic leukocytes and fibrosis. Synonym(s): lymphadenoma
Hodgkin-Key murmur - a musical diastolic murmur.
Hodgkin sarcoma
non-Hodgkin lymphoma - a lymphoma other than Hodgkin disease.
Medical Eponyms © Farlex 2012

non-Hodg·kin lym·pho·ma

(non-hoj'kin lim-fō'mă)
A lymphoma other than Hodgkin disease, classified nodular or diffuse tumor pattern and cell type.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
and Pedersen, N.T., Clinical significance of cyclin dependent kinase inhibitor p27Kip1 expression and proliferation in non Hodgkin's lymphoma: independent prognostic value of p27Kip1.
The most common pattern diffuse large B-cell Non Hodgkin lymphoma infiltraton was bone marrow followed by interstitial tissue.
Frequency and pattern of Bone Marrow infiltration in Non Hodgkin Lymphoma.
The Incidence of lymphoma is increasing largely contributed by Non Hodgkin's lymphoma (NHL).
This study was conducted to see the frequency and pattern of Non Hodgkin's lymphoma in our setup.
CONCLUSION: Non hodgkins lymphoma (diffuse large cell) nose and paranasal sinus is a rare entity and more than 50% of patients will have site of extranodal involvement as gastrointestinal tract and bone marrow.
To conclude, Non Hodgkin's lymphoma is 2 times more frequent than Hodgkin's lymphoma with greater male contribution.
Lymphoma, on broad spectrum, classifies into two major categories, Hodgkin's lymphoma (HL) and non Hodgkin's lymphoma (NHL) depending upon histopathologic evidence on biopsy taken from an enlarged lymph node.
Non Hodgkin's lymphomas are heterogeneous group of disorders originating in B- lymphocytes T- lymphocytes or natural killer cells.
Primary Extra Nodal Non Hodgkin Lymphoma: A 5 Year Retrospective Analysis.
DISCUSSION: Non Hodgkin's Lymphomas are a group of highly diverse malignancies and have a strong tendency to affect organs and tissues that do not ordinarily contain lymphoid cells.
Key Words: Non Hodgkin's Lymphoma, CD20, B cell Lymphoma

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