non-Hodgkin lymphoma

(redirected from Non Hodgkin Lymphoma)
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non-Hodg·kin lym·pho·ma (NHL),

a lymphoma other than Hodgkin disease, classified by Rappaport into a nodular or diffuse tumor pattern and by cell type; a working or international formulation separates such lymphomas into low-, intermediate-, and high-grade malignancy and into cytologic subtypes reflecting follicular center cell or other origin.

non-Hodgkin lymphoma

(nŏn′hŏj′kĭn) or

non-Hodgkin's lymphoma

(-kĭnz)
n.
Any of a large group of lymphomas that can be slow-growing or fast-growing, involve malignancies of either B cells or T cells, and are typically distinguished from Hodgkin lymphoma by the absence of Reed-Sternberg cells. Symptoms include enlarged lymph nodes, fever, night sweats, and weight loss.

non-Hodg·kin lym·pho·ma

(non-hoj'kin lim-fō'mă)
A lymphoma other than Hodgkin disease, classified by Rappaport into a nodular or diffuse tumor pattern and by cell type; a working or international formulation separates such lymphomas into low, intermediate, and high grade malignancy and into cytologic subtypes reflecting follicular center cell or other origin.
Enlarge picture
NON-HODGKIN LYMPHOMA: Bizarre-appearing lymphocytes revealing active mitosis (orig. mag. ×1000)

non-Hodgkin lymphoma

Abbreviation: NHL
Any of a group of malignant tumors of B or T lymphocytes. In 2008, the American Cancer Society estimated that about 66,100 Americans would be newly diagnosed with the disease. See: illustration; Hodgkin disease

Symptoms

Painless lymphadenopathy in two thirds of patients is the most frequent presenting symptom. Others have fever, night sweats, and loss of 10% or more of body weight in the 6 months before presenting with symptoms of infiltration into nonlymphoid tissue. Additional involvement is in peripheral areas such as epitrochlear nodes, the tonsillar area, and bone marrow. NHL is 50% more frequent in occurrence in men than in women of similar age. In most cases the cause of NHL is unknown, but patients who have received immunosuppressive agents have an over 100 times greater chance of developing NHL, probably because the immunosuppressive agents activate tumor viruses.

Treatment

Specific therapy depends on the type, grade, and stage of the lymphoma. Combination chemotherapies, bone marrow transplantation, radiation therapy, and photochemotherapy may be given, depending on the specific diagnosis.

See also: lymphoma

Hodgkin,

Thomas, English physician, 1798-1866.
Hodgkin disease - malignant neoplasm of lymphoid cells of uncertain origin, associated with inflammatory infiltration of lymphocytes and eosinophilic leukocytes and fibrosis. Synonym(s): lymphadenoma
Hodgkin-Key murmur - a musical diastolic murmur.
Hodgkin sarcoma
non-Hodgkin lymphoma - a lymphoma other than Hodgkin disease.

non-Hodg·kin lym·pho·ma

(non-hoj'kin lim-fō'mă)
A lymphoma other than Hodgkin disease, classified nodular or diffuse tumor pattern and cell type.
References in periodicals archive ?
Complete report on non hodgkin lymphoma market spread across 115 pages, covering 10 major NHL industry analysis headings and supported with 12 tables and 49 figures is now available at http://www.
The current developmental non hodgkin lymphoma market pipeline addresses present gaps in the market, dominated by cancer immunotherapies and inhibitors of cancer-associated signal transduction.
With significant differences in each subtype's genetic profile and current treatment, there is reduced scope for the development of a targeted non hodgkin lymphoma market therapy with cross-subtype activity.
This does not present non hodgkin lymphoma market drug development as an attractive investment in comparison to other indications in oncology, particularly as survival durations across many NHL subtypes are relatively strong, and likely the reason for low first-in-class innovation levels.
The scope of this non hodgkin lymphoma market report aims to answer multiple questions based on current industry status covering: There are 666 marketed products for non hodgkin lymphoma market, 95% of which are small molecules- what are the dominant mechanisms of action across marketed products?
The market for Non Hodgkin Lymphoma has significant unmet medical necessities in terms of demand for innovative drugs and novel technologies.

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