Rye Staging System

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Rye Staging System

A system for staging Hodgkin's disease delineated in 1966, which divided it into 4 distinct clinicopathological categories, based on data provided by the then popular method of lymphangiography. Cf Ann Arbor classification, Cotswolds classification.
Rye Classification–Hodgkin's disease
Lymphocytic predominant 10% of cases, more common in young adult ♂, usually early/low-stage disease without 'B' symptoms, 5-year survival: 90%
Nodular sclerosing 40%; more common in young adult ♀, usually early and low-stage disease with or without 'B' symptoms, 5-year survival: 70%
Mixed cellularity 40%; more common in young adult ♂, often stage II-III disease with or without 'B' symptoms, 5-year survival: 50%
Lymphocyte-depleted 10%; more common in older adult ?, usually stage III-IV disease with or without 'B' symptoms, 5-year survival, 30%
References in periodicals archive ?
The 25-year-old (below) was diagnosed with nodular sclerosing Hodgkin's lymphoma last October, but was given the all-clear in June after completing a course of chemotherapy.
The footballing world was shocked when Thompson revealed he had been diagnosed with nodular sclerosing Hodgkin's disease.
On Friday the Sky Bet League One club revealed medical tests had found Thompson, 24, had contracted nodular sclerosing Hodgkin's disease and Moore is now hoping the support of his immediate family can help him beat the cancer.
on 30 March 2009, nodular sclerosing HL was diagnosed via histopathological evaluation of a cervical lymph node biopsy specimen, and treatment with the ABVD protocol (adriamycin 25 mg [m.
Other differential diagnosis of an anterior mediastinal mass, which one could consider include a thymoma, thymic carcinoma, lymphoma especially the nodular sclerosing subtype of Hodgkin's disease which has a predilection for the anterior mediastinum and Castleman disease which is an uncommon entity in which giant lymph node hyperplasia involves the thorax in 70% of patients.
Histopathological examination of the inguinal lymph node and gluteal mass revealed nodular sclerosing Hodgkin disease.
However, the predominance of mixed cellularity Hodgkin lymphoma instead of nodular sclerosing Hodgkin lymphoma in the posttransplant setting suggests some influence exerted by the transplantation process.
The footballing world was shocked in November when Thompson revealed he had been diagnosed with nodular sclerosing Hodgkin's disease.
The 24-year-old has not played for Rovers since September due to feeling ill and medical tests have since found the former Rochdale winger has contracted nodular sclerosing Hodgkin's disease.
At this point, our differential diagnosis included nodular sclerosing Hodgkin disease, multiple myeloma or a reactive process.
Pathologic Diagnosis: Syncytial Variant of Nodular Sclerosing Hodgkin Disease