PGs synthesized by COX-2 increase the sensitivity of nociceptors
to the chemical mediators, thus increasing pain.
Selective inhibition of meningeal nociceptors
by botulinum neurotoxin type A: therapeutic implications for migraine and other pains.
This increase in perceived pain could be related to an increased sensitivity of nociceptors
, similar to the effects of the PPT algometer (Aboodarda et al., 2015; Cavanaugh et al., 2017).
TRP channels are involved with the pain-sensing neurons and primer afferent nociceptors
. NSAIDs have effects, such as inhibition, activation, or expression, on channels, which may be voltage-gated Na+, [Ca.sup.2+], or [K.sup.+] channels; ligand-gated [K.sup.+] channels; or TRP cation channels (7, 40).
Receptors, especially nociceptors
, send pain signals to the brain.
Afferent activity in nociceptor
fibres dislodges the central magnesium ion from the NMDA receptor, therefore allowing calcium influx into the cell.
The present study tested the mechanical noxious stimuli applied to the lips, where there are nociceptors
Psychophysical evidence of nociceptor
sensitization in vulvar vestibulitis syndrome.
There are three pharmacologic strategies for the management of post-endodontic pain: 1) Drugs that block inflammatory mediators that activate or sensitize pulpal nociceptors
(e.g., NSAIDs and glucocorticoids); 2) Drugs that block impulse propagation along the peripheral nerves; and 3) Drugs that block central mechanisms of hyperalgesia and pain perception.4 Glucocorticoids suppress the inflammatory mediators.
Spasticity can be caused by pain: sensory disturbances, excessive stress on joint and muscles when they are stretched, disruption of some muscle fibers occur and release substances which influence nociceptors
, the transmission of pain impulses may be suppressed via activation of mAChRs that are located on peripheral nociceptors
of the skin.
Hou et al., "Acid solution is a suitable medium for introducing QX-314 into nociceptors
through TRPV1 channels to produce sensory-specific analgesic effects," PLoS One, vol.