Keywords: Amines, Bis-thiourea, MII(tu)2Cl2, NaBH4, Nitro compounds, Reduction.
Reduction of nitro compounds to the corresponding amines is one of the most important synthetic transformations in organic chemistry [1-4].
It is well known that the alone NaBH4 does not reduce nitro compounds under ordinary conditions.
In line with the outlined strategies, herein, we wish to introduce an easy, efficient and practical protocol for solvent-free reduction of various aromatic and aliphatic nitro compounds to the corresponding amines with NaBH4 in the presence of bis-thiourea complexes of bivalent cobalt, nickel, copper and zinc chlorides at room temperature (Scheme 1).
A literature review shows that though the application of NaBH4 in the presence of various Lewis acids or promoters has been used for reduction of nitro compounds to amines, however, the combination system of bis-thiourea complexes of bivalent transition metal chlorides with NaBH4 has not been investigated yet.
We also found that the nitro compounds by themselves had significant bacteria-killing activity, and that activity was more persistent than the chlorate activity by itself.
coli were treated with or without chlorate and with or without an appropriate amount of nitro compound.