nitric oxide synthase

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ni·tric ox·ide syn·thase (NO syn·thase, NOS),

an enzyme that catalyzes the reaction of l-arginine with 2O2 and 1.5NADPH to form NO, l-citrulline, 1.5NADP+, and 2H2O; there are an inducible and two constitutive forms of this enzyme: the constitutive forms play significant roles in regulating vascular tone, tissue blood flow, renal function, and others; in bone, brain, endothelium, granulocytes, pancreatic Z-cells, and peripheral nerves, the constitutive forms depend on calcium-calmodulin; in brain, the enzyme is cytosolic; in endothelium, it is membrane bound; the inducible form of the enzyme (for example, by endotoxin) in hepatocytes, Kupffer cells, macrophages, and smooth muscle is not calmodulin dependent.

nitric oxide synthase

Abbreviation: NOS
An enzyme that synthesizes nitric oxide from arginine; present in the central nervous system, the lining of blood vessels, the heart, joints, some autonomic neurons, and other organs.
See also: synthase

nitric oxide synthase

One of three enzymes that catalyze the synthesis of NITRIC OXIDE in blood vessel ENDOTHELIUM, nerve fibres and MACROPHAGES. These enzymes are coded for, respectively, on chromosomes 7, 12 and 17. They act by splitting off a nitrogen atom from the amino acid L-arginine which is then combined with an oxygen atom from molecular oxygen to form NO.
References in periodicals archive ?
Wung, "Tannin 1-[alpha]-O-galloylpunicalagin induces the calcium-dependent activation of endothelial nitric-oxide synthase via the phosphatidylinositol 3-kinase/Akt pathway in endothelial cells," Molecular Nutrition and Food Research, vol.
Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitric-oxide synthase, superoxide, and cyclooxygenase metabolites," Journal of Pharmacology and Experimental Therapeutics, vol.
Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice," Journal of Pharmacology and Experimental Therapeutics, vol.
Functional significance of cytosolic endothelial nitric-oxide synthase (eNOS): regulation of hyperpermeability.
Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells.
Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase.
Superoxide generation from endothelial nitric-oxide synthase.
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.
2+]-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells.
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation.
Compartmentalised inducible nitric-oxide synthase activity in septic shock.