nitric oxide synthase


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Related to nitric oxide synthase: Neuronal Nitric Oxide Synthase

ni·tric ox·ide syn·thase (NO syn·thase, NOS),

an enzyme that catalyzes the reaction of l-arginine with 2O2 and 1.5NADPH to form NO, l-citrulline, 1.5NADP+, and 2H2O; there are an inducible and two constitutive forms of this enzyme: the constitutive forms play significant roles in regulating vascular tone, tissue blood flow, renal function, and others; in bone, brain, endothelium, granulocytes, pancreatic Z-cells, and peripheral nerves, the constitutive forms depend on calcium-calmodulin; in brain, the enzyme is cytosolic; in endothelium, it is membrane bound; the inducible form of the enzyme (for example, by endotoxin) in hepatocytes, Kupffer cells, macrophages, and smooth muscle is not calmodulin dependent.

nitric oxide synthase

Abbreviation: NOS
An enzyme that synthesizes nitric oxide from arginine; present in the central nervous system, the lining of blood vessels, the heart, joints, some autonomic neurons, and other organs.
See also: synthase

nitric oxide synthase

One of three enzymes that catalyze the synthesis of NITRIC OXIDE in blood vessel ENDOTHELIUM, nerve fibres and MACROPHAGES. These enzymes are coded for, respectively, on chromosomes 7, 12 and 17. They act by splitting off a nitrogen atom from the amino acid L-arginine which is then combined with an oxygen atom from molecular oxygen to form NO.
References in periodicals archive ?
Neuronal nitric oxide synthase activity in the paraventricular nucleus buffers central endothelin-1- induced pressor response and vasopressin secretion.
Nitric oxide synthase in spermatozoa and blood testosterone levels also increased significantly.
Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury.
Endothelial nitric oxide synthase gene G894T polymorphism and myocardial infarction: a meta-analysis of 34 studies involving 21068 subjects.
Leal, "Consequences of nitric oxide synthase inhibition during bovine oocyte maturation on meiosis and embryo development," Reproduction in Domestic Animals, vol.
Effect of chitosan on nitric oxide content and inducible nitric oxide synthase activity in serum and expression of inducible nitric oxide synthase mRNA in small intestine of broiler chickens.
Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells.
Inhibition of Nitric oxide Synthase Delays Wound Healing.
The vasodilator molecule of nitric oxide (NO) is produced from L-arginine by endothelial nitric oxide synthase (eNOS).
Introduction: In this study, we investigated the association of migraine with the Variable Number of Tandem Repeats (VNTR), repeated as 27 base pair, gene polymorphism in intron 4 of the endothelial nitric oxide synthase (e/VOS) and the insertion/deletion of angiotensin converting enzyme (ACE) gene polymorphisms.

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