NEK2

(redirected from NimA-related protein kinase 2)

NEK2

A gene on chromosome 1q32.2-q41 that encodes a NEK serine/threonine protein kinase involved controlling centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. It phosphorylates CDC20, CROCC, CEP250, HMGA2, MAD2L1, NDC80, NECAB3, NEK11, NINL, NPM1, PPP1CC and SGOL1; it is essential for localisation of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome.
References in periodicals archive ?
29) Additional kinase genes involved in cell-cycle regulation that were down-regulated in our samples belong to the serine/threonine protein-kinase group (PKC-[alpha], SGK, NIMA-related protein kinase 2 and 3).