Nikolsky sign

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Related to Nikolsky sign: pemphigus, bullous pemphigoid, Steven Johnson syndrome

Ni·kol·sky sign

(ni-kol'skē),

a peculiar vulnerability of the skin in pemphigus vulgaris; the apparently normal epidermis may be separated at the basal layer and rubbed off when pressed with a sliding motion.

Ni·kol·sky sign

(ni-kol'skē sīn)

A peculiar vulnerability of the skin in pemphigus vulgaris; the apparently normal epidermis can be separated at the basal layer and rubbed off when pressed with a sliding motion.

Nikolsky,

Pyotr V., Russian dermatologist, 1858-1940.

Nikolsky sign - a peculiar vulnerability of the skin in pemphigus vulgaris.

Ni·kol·sky sign

(ni-kol'skē sīn)

A peculiar vulnerability of the skin in pemphigus vulgaris; the apparently normal epidermis can be separated at the basal layer and rubbed off when pressed with a sliding motion.

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References in periodicals archive ?

This compromise in the structural integrity of the superficial epidermis is responsible for the fragile nature of the bullae seen in SSSS and the positive Nikolsky sign.

Pediatric dermatology consult: staphylococcal scalded skin syndrome

Four days later he developed multiple new flaccid bullae adjacent to the preexisting lesions along the same dermatome with a positive Nikolsky sign (Figure 1).

A variant of Wolf's isotopic response-overriding of two Blistering diseases

Early warning signs in drug allergies (2) Type of reaction Findings Early reactions Extensive pruritus Rhinoconjunctivitis, obstructive respiratory symptoms, nausea, vomiting Pruritus around the mouth, pruritus in the palms and soles Sudden erythema on the skin together with conjunctivitis and rhinitis Delayed reactions Fever, malaise Long-term findings after discontinuation of the drug Lymphadenopathy Pain and burning in the skin Bulleous lesions, epidermal separation (Nikolsky sign) Mucosal involvement Edema in the face and diffuse erythematous swelling Confluent lesions in extensive skin areas Eosinophilia (>1.5x[10.sup.9]/L) Hepatic involvement