Nikolsky's sign


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Nikolsky's sign

 [nĭ-kol´skēz]
in pemphigus vulgaris and some other bullous diseases, the outer epidermis separates easily from the basal layer on exertion of firm sliding manual pressure.
References in periodicals archive ?
Follow-up Patients were followed up regularly and monitored for any side effects of the therapy, clinical activity of the disease in terms of healing of existing lesions, appearance of new lesions and Nikolsky's sign.
Bullae with a positive Nikolsky's sign is present in TEN likewise, mucosal lesions accompany in all conscience.
Bulla spread sign and nikolsky's sign were negative.
* Lesions can follow a minor trauma, called Nikolsky's Sign, where cells pull apart and blister and lesions develop because the adhesion between cells is weakened.
A definitive diagnosis of PV is made when Nikolsky's sign is positive, in the presence of acantholysis in histopathology and by direct immunofluorescence [2].