Nikolsky's sign


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Nikolsky's sign

 [nĭ-kol´skēz]
in pemphigus vulgaris and some other bullous diseases, the outer epidermis separates easily from the basal layer on exertion of firm sliding manual pressure.

Nikolsky's sign

[nikol′skēz]
Etymology: Petr V. Nikolsky, Russian dermatologist, 1858-1940
easy separation of the stratum corneum layer of the epidermis from the basal cell layer by rubbing apparently normal skin areas, found in pemphigus and a few other bullous diseases.

Nikolsky's sign

in pemphigus vulgaris and some other bullous diseases, the outer epidermis separates easily from the basal layer on exertion of firm sliding manual pressure.
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References in periodicals archive ?
Nikolsky's sign (separation of the upper epidermis with gentle pressure) is a classic finding.
Derm emergencies--detecting early signs of trouble: life-threatening dermatologic conditions do not always present with classic findings. This review--and the accompanying images--will help you recognize and respond to them without delay
But dexamethasone group showed statistically more significant improvement than prednisolone group in all clinical parameters except Nikolsky's sign.
Safety of parenteral dexamethasone vs. oral prednisolone in the treatment of pemphigus vulgaris
A positive Nikolsky's sign is characteristic of pemphigns vulgaris.
Rupturing bullae not responding to antibiotics

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