Recently, a synergistic effect of aspirin with nifurtimox
and benznidazole was observed on T.
The patient's rash and parasitemia resolved after 10 days of nifurtimox
To decrease the risk for morbidity and mortality, infected persons should be treated as early in the course of infection as possible with either benznidazole (not available in the United States) or nifurtimox
(available through the CDC Drug Service, telephone  639-3670).
Jackson, Q.Miao et al., "Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox
treatment," BMC Infectious Diseases, vol.
The newborn began a 60-day course of nifurtimox
(10 mg/kg/d) at 20 weeks of age and had no adverse effects.
The situation of CCC patients is worrisome because the specific anti-T cruzi drugs, currently limited to benznidazol and nifurtimox
, show limited efficacy in chronically infected patients.
was given (and was well tolerated) after the patient's cutaneous and blood status had normalized.
From 2001 to 2003, a total of 44,247 patients were treated with pentamidine (31.5%), suramin (5.8%), the combination pentamidine-suramin (0.2%), melarsoprol (55.2%), eflornithine (0.85%), nifurtimox
(2.6%), and the combination melarsoprol-nifurtimox (3.5%) (because nifurtimox
is not registered for use against HAT in DRC, it was given on a compassionate basis when no other drugs were available or when melarsoprol treatment failed).
cruzi can be successfully treated with nifurtimox
or benzonidazole (12,14).
It is vital that a mechanism is in place to allow physicians working in nonendemic areas who are involved in the management of patients from trypanosomiasis-endemic areas to have access to suramin and several other essential but rarely used agents (such as melarsoprol, eflornithine, nifurtimox
, and benznidazole; the last two drugs used for treatment of South American trypanosomiasis) from a central repository 24 hours a day, 7 days a week.
Bayer presented results from the CHICO part of the phase 3 clinical study of investigational nifurtimox
in pediatric patients with Chagas disease at the "XV Taller sobre la enfermedad de Chagas" conference in Barcelona, Spain.