A randomized trial to assess the efficacy and safety of abt-126, a selective alpha7 nicotinic acetylcholine receptor
agonist, in the treatment of cognitive impairment in schizophrenia.
A missense mutation in the neuronal nicotinic acetylcholine receptor
alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy.
More than 10 nicotinic acetylcholine receptor
genes have been cloned in insects and post-translational modifications have been observed on subunit mRNAs (Grauso et al.
The IRAC mode of action groups to which the above insecticides belong are as follows: fipronil (2B, GABA-gated chloride channel antagonists), lambda-cyhalothrin (3A, Sodium channel modulators), imidacloprid, thiacloprid and thiamethoxam (4A, Nicotinic acetylcholine receptor
[nAChR] agonists), and spinosad (5, Nicotinic acetylcholine receptor
[nAChR] allosteric activators).
Varenicline, due to its unique mechanism of action as a partial agonist of [alpha]4[beta]2 nicotinic acetylcholine receptors
, reduces withdrawal symptoms of smoking cessation by maintaining a modest level of dopamine in brain.
EnVivo's lead product, EVP-6124, is an alpha-7 nicotinic acetylcholine receptor
MG autoantibodies attack the postsynaptic nicotinic acetylcholine receptor
of the muscle affecting cholinergic transmission (Meriggioli & Sanders, 2009).
This active ingredient regulates epidermal homeostasis by controlling calcium inflow into keratinocytes via the nicotinic acetylcholine receptor
(nAChRs) pathway, according to the company.
Cytisine is a partial agonist that binds with high affinity to a subtype of the nicotinic acetylcholine receptor
, which is also the primary target of the smoking cessation drug varenicline.
Her dissertation entitled The role of nicotinic acetylcholine receptor
a4~32 and cz7 in nicotine-ethanol interaction and cross-tolerance: Functional correlation with cerebellar nitric oxide.
Detection of autoantibodies to the neuromuscular nicotinic acetylcholine receptor
(ACHR) has proved useful in assisting in the diagnosis of MG; however, the complexity of this disease, combined with the variety of antibodies associated with MG, has led to multiple attempts to correlate disease severity with antibody detection and concentration.
Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor