PSEN1 and PSEN2 are part of the [gamma]-secretase complex, which also includes nicastrin
, anterior pharynx-defective 1, and presenilin enhancer 2 .
Presenilin-1 is one of 4 core components of the [gamma]-secretase protein complex along with nicastrin
(NCT), presenilin enhancer 2 (PEN2), and anterior pharynx-defective 1 (APH1).
Furthermore, expression of components of Notch-1 activating [gamma]-secretase complex (presenilin 1, nicastrin
, Pen2, and APH-1) was also suppressed.
This complex is a multisubunit protease comprised of four components: presenilin-1 and presenilin-2 (PS1 and PS2, resp.), nicastrin
, anterior pharynx defective-1 (APH-1), and presenilin enhancer 2 (PEN-2).
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
. J Neurosci 2010;30:1648-56.
Four proteins are required for this complex: PS1 or PS2, nicastrin
, presenilin enhancer 2, and anterior pharynx defective 1.
The [beta]-secretase (BACE1, transmembrane aspartyl protease) initiates endoproteolytic cleavage giving rise to N-terminus of A[beta] ([beta]-secretase cleaved APP to [beta]CTF as the intermediate) followed by [gamma]-secretase (membrane-embedded aspartyl protease complex consisting of presenilin, PS), presenilin enhancer-2 (Pen-2), anterior pharynx defective-1 (Aph-1), and nicastrin
, which reveals the C-terminus of A[beta] .
mutations in French families with hidradenitis suppurativa.
[gamma]-Secretase is a lipid bilayer-embedded aspartyl protease consisting of four core subunits; nicastrin
, Aph-1, Pen-2, and presenilin.
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin
, Aph-1, and Pen-2.
Gamma secretase is a membrane protein complex comprised of presenilin, nicastrin
, Aph-1 and Pen-2.