TBRG1

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TBRG1

A gene on chromosome 11q24.2 that encodes a protein, widely expressed but at low levels, which acts as a growth inhibitor. It can activate p53/TP53, causing G1 arrest, and collaborates with CDKN2A to restrict cell proliferation. TRBG1 redistributes CDKN2A into the nucleoplasm, is involved in maintaining chromosomal stability and has tumour suppressor activity.

Molecular pathology
TBRG1’s expression is reduced in primary carcinomas of lung, liver, breast, pancreas and kidney, chronic lymphocytic leukaemia, and in diffuse large B-cell lymphoma.
References in periodicals archive ?
Cities can take advantage of NIAM by encouraging their constituents to take advantage of government sponsored immunization programs.
Koj tham puas tau me ntsis txog niam Nkauj Kab Yeeb los sis nkawm niam txiv Dab Pog?
They found that normalization, used in RDM, resulted in higher-quality data design, took less time, and was preferred by analysts over the information analysis technique used in NIAM.
Niam added that the governing parties support the appointment and approval of the prime minister by the president of the republic to fit with the presidential system.
Lebanese filmmaker Niam Itani will be competing at the Venice film festival with her short film "Super.
In statements to Sudan Tribune following the meeting, Niam said he and Hamid Mumtaz of the ruling National Congress Party represented the government, while the opposition is represented by Amin Banani and Mohamed al-Alem.
He has also managed major property holdings for NIAM and others.
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Prince Niam Pious from the Afridonia Cultural Organisation said: "When I heard about these toys I just could not believe it.
Former DRA Minister of Reconstruction, Development and Infrastructure and former rebel chief negotiator Tadjadine Bechir Niam, told Sudan Tribune that the parties to the DDPD agreement would discuss work arrangements for the 800 workers of the authority.
Project development and construction company Skanska AB (STO:SKAB) announced today the sale of the office property Klara Strand (Blekholmen 1), situated by the Stockholm Central Station, to the real estate investor NIAM, for approximately SEK1.
But Young, signed by the Wasps in the summer, admits he has never felt better - and a lot of that is down to Alloa physio Niam Mohammed.