Comparison of this patient's hantavirus sequence with those of New York virus (strains NY-1 and RI-1) and SNV (strains NMH10, CC74 and CC107) identified a nucleotide difference of 14.8% to 19.6% and an amino acid difference of 2.3% to 3.1% (14-16).
Nucleotide and amino acid differences of 15.6% to 21.5% and 1.5% to 7.4%, respectively, were seen when this fragment was compared with the more distantly related Peromyscus-borne hantaviruses, including Blue River virus (strains Indiana and Oklahoma), New York virus (strains RI-1, NY-1, and NY-2), and SNV (strains NM H10, CC74, and CC 107) (15-19).
The CDC scientists had speculated that the New York virus
would be most closely related to a West Nile strain called Volvograd, which caused an outbreak in that Russian city last year.
Although these authors found evidence of cospeciation between the rodent host phylogeny and the host-borne hantavirus phylogeny, evidence of host switching was observed with Peromyscus leucopus--borne New York virus
grouped with P.
The next most closely related viruses are those detected in the northeastern United States, referred to as New York virus (34).
The New York virus, and the Blue River virus lineages found in Indiana and Oklahoma, appear associated with genetically distinct P.
Investigations of HPS cases in the United States have resulted not only in studies of the deer mouse and SNV but also in the identification of three additional host-virus relationships that maintain hantaviruses responsible for human disease (New York virus carried by the white-footed mouse, Peromyscus leucopus [Figure 1] ; Black Creek Canal virus carried by the cotton rat, Sigmodon hispidus ; and Bayou virus carried by the rice rat, Oryzomys palustris ).
This assay would detect (but not distinguish among) infections by New York virus (from the white-footed mouse ), Prospect Hill-like viruses (from arvicoline rodents ), El Moro Canyon virus (from the Western harvest mouse ), Black Creek Canal virus (from the cotton rat ), and Bayou virus (from the rice rat ).